A5068628918- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- interferon and immune responses
- Carcinogens and Genotoxicity Assessment
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Telomeres, Telomerase, and Senescence
- Immune Response and Inflammation
- Agriculture and Farm Safety
- BRCA gene mutations in cancer
- Cancer-related Molecular Pathways
- Cytomegalovirus and herpesvirus research
- Migration, Ethnicity, and Economy
- RNA regulation and disease
- Mitochondrial Function and Pathology
- Architecture, Design, and Social History
- Mesenchymal stem cell research
- Bacterial Genetics and Biotechnology
- Arsenic contamination and mitigation
- Genetic factors in colorectal cancer
- Canadian Identity and History
- RNA modifications and cancer
Tufts University
2022
The University of Texas MD Anderson Cancer Center
2017-2021
The University of Texas Health Science Center at Houston
2017-2021
Institut d'Investigació Biomédica de Bellvitge
2019
Bellvitge University Hospital
2019
Universitat de Barcelona
2019
University of Southern Maine
2013
Telomeres are nucleoprotein structures present at the terminal region of chromosomes. Mutations in genes coding for proteins involved telomere maintenance causative a number disorders known as telomeropathies. The genetic origin these diseases is heterogeneous and has not been determined significant proportion patients. This article describes characterization cohort Telomere length was by Southern blot quantitative PCR. Nucleotide variants were analyzed either high-resolution melting...
In mammalian cells, specialized DNA polymerase ζ (pol ζ) contributes to genomic stability during normal replication. Disruption of the catalytic subunit Rev3l is toxic and results in constitutive chromosome damage, including micronuclei. As manifestations this stress are unknown, we examined transcriptome pol ζ-defective cells by RNA sequencing (RNA-seq). Expression 1,117 transcripts altered ≥4-fold Rev3l-disrupted with a pattern consistent an induction innate immune response. Increased...
ABSTRACT DNA polymerase pol ζ is regarded as a specialized for bypass of lesions. In mammalian cells, also contributes to genomic stability during normal replication. Disruption Rev3l (the catalytic subunit ζ) toxic cells and mice, with increased constitutive chromosome damage, including micronuclei. As the cellular manifestations this stress have remained unexplored, we measured genome-wide transcriptional changes by RNA-seq in ζ-defective cells. Expression 1117 transcripts was altered...