A5020378682- Toxoplasma gondii Research Studies
- interferon and immune responses
- Inflammasome and immune disorders
- Rabies epidemiology and control
- Immune cells in cancer
- Herpesvirus Infections and Treatments
- Ferroptosis and cancer prognosis
- Immune responses and vaccinations
- Parasitic Infections and Diagnostics
- Protist diversity and phylogeny
- Immunotherapy and Immune Responses
- Research on Leishmaniasis Studies
- Hepatitis B Virus Studies
- Trypanosoma species research and implications
- Bacteriophages and microbial interactions
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Cytomegalovirus and herpesvirus research
- Phytochemical compounds biological activities
- Viral Infections and Vectors
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
Mohammed Bin Rashid University of Medicine and Health Sciences
2022-2024
American University of Beirut
2020-2023
Université de Montpellier
2021-2023
Centre National de la Recherche Scientifique
2021-2023
Inserm
2023
Toxoplasmosis is a neglected parasitic disease necessitating public health control. Host cell invasion by Toxoplasma occurs at different stages of the parasite's life cycle and crucial for survival establishment infection. In tachyzoites, which are responsible acute toxoplasmosis, involves formation molecular bridge between parasite host membranes, referred to as moving junction (MJ). The MJ shaped assembly AMA1 RON2, part complex involving additional RONs. While this essential process well...
Toxoplasma gondii is a prevalent parasite of medical and veterinary importance. Tachyzoïtes bradyzoïtes are responsible for acute chronic toxoplasmosis (AT CT), respectively. In immunocompetent hosts, AT evolves into persistent CT, which can reactivate in immunocompromised patients with dire consequences. Imiquimod an efficient immunomodulatory drug against certain viral parasitic infections. vivo , treatment Imiquimod, throughout AT, reduces the number brain cysts while rendering remaining...
Cutaneous Leishmaniasis (CL) is a neglected tropical disease, classified by the World Health Organization (WHO) as one of most unrestrained diseases. The Syrian war and significant displacement refugees aggravated spread this ailment into several neighboring countries in Eastern Mediterranean Region (EMR). In Syria, Leishmania tropica identified aggressive endemic species, causing localized or generalized lesions, often chronic relapsing. Pentavalent antimonial drugs are currently used first...
The IFIH1 gene, encoding melanoma differentiation-associated protein 5 (MDA5), is an indispensable innate immune regulator involved in the early detection of viral infections. Previous studies described MDA5 dysregulation weakened immunological responses, and increased susceptibility to microbial infections autoimmune disorders. Monoallelic gain-of-function gene has been associated with multisystem disorders, namely Aicardi-Goutieres Singleton-Merten syndromes, while biallelic loss causes...
The succinate receptor, SUCNR1, has been attributed to tumor progression, metastasis, and immune response modulation upon its activation via the oncometabolite succinate. Nonetheless, little is known about prognostic relevance of SUCNR1 association with infiltrates microbiota in renal cell carcinoma (RCC). Herein, publicly available platforms including Human Protein Atlas, cBioPortal, TIMER2.0, TISIDB were utilized depict a divergent implication microenvironment clear RCC (KIRC) papillary...
The succinate receptor, SUCNR1, has been attributed to tumor progression, metastasis, and im-mune response modulation upon its activation via the oncometabolite succinate. Nonetheless, lit-tle is known about SUCNR1 prognostic relevance association with immune infil-trates microbiota in renal cell carcinoma (RCC). Herein, publicly available platforms in-cluding Human Protein Atlas, cBioPortal, TIMER2, TISIDB were utilized depict a diver-gent implication of microenvironment clear RCC (KIRC)...
Toxoplasmosis is a prevalent parasitic disease caused by Toxoplasma gondii ( T. ). Under the control of host immune system, persists as latent bradyzoite cysts. Immunosuppression leads to their reactivation, potentially life-threatening condition. Interferon-gamma (IFN-γ) controls different stages toxoplasmosis. Here, we addressed role parasite surface antigen P18, belonging Surface-Antigen 1 (SAG-1) Related Sequence (SRS) family, in cyst-forming strain. Deletion P18 gene (KO ) impaired...
Abstract The IFIH1 gene, encoding melanoma differentiation-associated protein 5 (MDA5), is an indispensable innate immune regulator involved in the early detection of viral infections. Previous studies described MDA5 dysregulation linking it to weakened immunological responses, and increased susceptibility microbial infections autoimmune disorders. Monoallelic gain-of-function gene has been associated with multisystem disorders, namely Aicardi-Goutieres Singleton-Merten syndromes, while...
<title>Abstract</title> The <italic>IFIH1</italic> gene, encoding melanoma differentiation-associated protein 5 (MDA5), is an indispensable innate immune regulator involved in the early detection of viral infections. Previous studies described MDA5 dysregulation linking it to weakened immunological responses, and increased susceptibility microbial infections autoimmune disorders. Monoallelic gain-of-function gene has been associated with multisystem disorders, namely Aicardi-Goutieres...
Toxoplasma gondii is a single-celled parasitic eukaryote that evolved to successfully propagate in any nucleated cell. As with other eukaryote, its life cycle regulated by signaling pathways controlled kinases and phosphatases. T. encodes an atypical bacterial-like phosphatase absent from mammalian genomes, named Shelph, after first identification the psychrophilic bacterium Schewanella sp. Here, we demonstrate Shelph active localized parasite endoplasmic reticulum. The phenotyping of shelph...