A5058254865- Enzyme Catalysis and Immobilization
- Microbial metabolism and enzyme function
- Photosynthetic Processes and Mechanisms
- Microbial Metabolic Engineering and Bioproduction
- Plant tissue culture and regeneration
- Alcohol Consumption and Health Effects
University of Wisconsin–Madison
2024
University of Minnesota
2021
Normal cellular processes give rise to toxic metabolites that cells must mitigate. Formaldehyde is a universal stressor and potent metabolic toxin generated in organisms from bacteria humans. Methylotrophic such as Methylorubrum extorquens face an acute challenge due their production of formaldehyde obligate central intermediate single-carbon metabolism. Mechanisms sense respond were speculated exist methylotrophs for decades but had never been discovered. Here, we identify member the DUF336...
Abstract Intracellular pools of deoxynucleoside triphosphates (dNTPs) are strictly maintained throughout the cell cycle to ensure accurate and efficient DNA replication. synthesis requires an abundance dNTPs, but elevated dNTP concentrations in nonreplicating cells delay entry into S phase. Enzymes known as deoxyguanosine triphosphate triphosphohydrolases (Dgts) hydrolyze dNTPs deoxynucleosides triphosphates, we propose that Dgts restrict promote G1 phase transition. We characterized a Dgt...