A5003969204- Opioid Use Disorder Treatment
- Substance Abuse Treatment and Outcomes
- Poisoning and overdose treatments
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Musculoskeletal pain and rehabilitation
- Posttraumatic Stress Disorder Research
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac pacing and defibrillation studies
- Pain Mechanisms and Treatments
- Suicide and Self-Harm Studies
- Primary Care and Health Outcomes
- Attention Deficit Hyperactivity Disorder
- Prenatal Substance Exposure Effects
- Family and Patient Care in Intensive Care Units
- Migration, Health and Trauma
- Fungal Biology and Applications
- Treatment of Major Depression
- Empathy and Medical Education
- Pneumocystis jirovecii pneumonia detection and treatment
- Child Abuse and Trauma
- Alcohol Consumption and Health Effects
- HIV, Drug Use, Sexual Risk
- Palliative Care and End-of-Life Issues
- Plant biochemistry and biosynthesis
University of Washington
2008-2025
Washington State Department of Health
2023
Behavioral Tech Research, Inc.
2023
University of Washington Medical Center
2023
Harborview Medical Center
2021-2023
VA Puget Sound Health Care System
2023
United States Department of Veterans Affairs
2023
Seattle University
2022
University of California, San Francisco
2019-2020
San Francisco General Hospital
2020
Despite the wealth of knowledge regarding mechanisms action and resistance to azole antifungals, very little is known about how azoles are imported into pathogenic fungal cells. Here in-vitro accumulation import Fluconazole (FLC) was examined in fungus, Candida albicans. In energized cells, FLC correlates inversely with expression ATP-dependent efflux pumps. de-energized all strains accumulate FLC, suggesting that not ATP-dependent. The kinetics cells displays saturation a Km 0.64 uM Vmax...
Abstract Background There is little study of lifetime trauma exposure among individuals engaged in medication treatment for opioid use disorder (MOUD). A multisite provided the opportunity to examine prevalence and differences by gender, PTSD status, chronic pain. Methods cross-sectional examined baseline data from participants ( N = 303) enrolled a randomized controlled trial mind–body intervention as an adjunct MOUD. All were stabilized on Measures included Trauma Life Events Questionnaire...
The tetracycline (TET) promoter has been used in several systems as an inducible regulator of gene expression. In control analyses, the standard Candida albicans laboratory strain SC5314 was found to have altered susceptibility a variety antifungal drugs presence relatively high concentrations (50–200 μg ml−1) TET. Altered most notable with exposure amphotericin B (AMB), 32-fold increase susceptibility, and terbinafine (TRB), decrease susceptibility. TET/AMB synergy observed clinical...
Safer use strategies (SUS) are behaviors before, during, and after drug to moderate and/or mitigate unwanted consequences. As treatment of substance disorders becomes more common in primary care, offering SUS care merits exploration. We explored acceptability using a convergent parallel mixed-method design consisting patient clinician semi-structured interviews surveys. Participants were recruited from clinics involved multi-state practice research network. Patients with lifetime stimulant...
Importance Drug overdose (OD) is a public health challenge and an important cause of out-of-hospital cardiac arrest (OHCA). Existing studies evaluating OD-related OHCA (OD-OHCA) either aggregate all drugs or focus on opioids. The epidemiology, presentation, outcomes drug-specific are largely unknown. Objective To evaluate the temporal pattern, clinical care, adult patients with overall according to profile. Design, Setting, Participants This cohort study adults in King County Washington was...
Background: The relationships between opioid use disorder (OUD), chronic pain, and mental health distress are complex multidirectional. objective of this exploratory study was to examine the relationship conditions Chronic pain severity interference among patients stabilized on either buprenorphine or methadone. Methods: We report baseline data from a randomized trial mind-body intervention conducted at 5 outpatient clinics that provided methadone treatment. Validated scales were used...
Methamphetamine use is on the rise with increasing emergency department (ED) visits, behavioral health crises, and deaths associated overdose. Emergency clinicians describe methamphetamine as a significant problem high resource utilization violence against staff, but little known about patient's perspective. In this study our objective was to identify motivations for initiation continued among people who their experiences in ED guide future ED-based approaches.This qualitative of adults...
Objectives Contingency management (CM) is one of the most effective treatments for stimulant use disorder but has not been leveraged people with stimulant-associated cardiomyopathy (SA-CMP), a chronic health condition significant morbidity and mortality. We aimed to determine feasibility acceptability multidisciplinary addiction/cardiology clinic CM patients SA-CMP explore barriers facilitators engagement recovery. Methods recruited hospitalization in past 6 months, heart failure reduced...
Buprenorphine is increasingly used to treat pain in patients with sickle cell disease but optimal timing and approach for transitioning from full agonist opioids buprenorphine unknown. We present the case of a 22-year-old woman acute on chronic who transitioned high-dose oxycodone buprenorphine/naloxone during hospital stay vaso-occlusive episode. Utilizing microdosing minimize withdrawal, was gradually uptitrated while she received opioids. During transition, experienced some withdrawal...
Co-occurring substance use disorders (SUDs) and heart failure (HF) create a perfect storm: the drug drives cardiac pathophysiology, while complex psychosocial factors interfere with treatment efforts. Patients SUDs HF are less likely to engage in care due chaotic patterns, poverty, co-occurring mental illness, mistrust healthcare system decreased social support. The stigma of can also negatively bias providers, further complicating alliance. SUDs complicate at least 15% hospitalisations.1...
<title>Abstract</title> Background There is little study of lifetime trauma exposure among individuals engaged in medication treatment for opioid use disorder (MOUD). A multisite provided the opportunity to examine prevalence and differences by gender, PTSD status, chronic pain. Methods cross-sectional examined baseline data from participants (N = 303) enrolled a randomized controlled trial mind-body intervention as an adjunct MOUD. All were stabilized on Measures included Trauma Life Events...
What Should I Know About Opioids and Living With Chronic Pain?At one time, chronic pain (lasting longer than 3 months) was routinely treated with opioid medications (oxycodone, morphine, codeine, etc).But we now know that opioids are less effective more risky thought, so many people choosing other ways to treat pain.What Are the Risks of Opioids?Even when taken as directed, can cause side effects.These include tolerance (requiring medication have same effect), dependence (developing...
Tuegel, Courtney MD; Farris, Stephen D. Kantner, Carl W. PhD; Leyde, Sarah DePhilippis, Dominick Kennedy, Amy J. MD, MS Author Information