A5024096833- Pharmaceutical and Antibiotic Environmental Impacts
- Spectroscopy and Chemometric Analyses
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Chemistry and Chromatography
- Analytical chemistry methods development
- Advanced oxidation water treatment
- Molecular spectroscopy and chirality
- Metabolomics and Mass Spectrometry Studies
- NMR spectroscopy and applications
- Water Quality Monitoring and Analysis
- Fluorine in Organic Chemistry
- Spectroscopy Techniques in Biomedical and Chemical Research
- Protein purification and stability
- Insect and Pesticide Research
- Electrochemical Analysis and Applications
- Pesticide Residue Analysis and Safety
- Environmental Toxicology and Ecotoxicology
- Advanced Chemical Sensor Technologies
- Microbial Metabolic Engineering and Bioproduction
- Antibiotic Resistance in Bacteria
- Electron Spin Resonance Studies
- Advanced NMR Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Biosimilars and Bioanalytical Methods
Hochschule Niederrhein
2016-2025
Weatherford College
2023
Radboud University Nijmegen
2011-2016
DSM (Switzerland)
2012-2013
Merck (Netherlands)
2011
MSD (Netherlands)
2011
Abstract The occurrence of highly exothermic and potential runaway reactions represents a significant hazard to workers, facilities, the surrounding ecosystem. Due their high reaction velocity, these often prove difficult monitor. In many instances, recorded data result from several single-quantity sensors, such as temperature pressure sensors. Yet, deviations anticipated process, thus potentially hazardous parameters, may only be identified by combination sensor data, leaving cause...
Abstract The European Union requires environmental monitoring of the antidepressant drug venlafaxine. Advanced oxidation processes provide a remedy against spread micropollutants. In this study, photoinduced and electrochemical decompositions venlafaxine were investigated in terms mechanism efficacy using high-performance liquid chromatography coupled to high-resolution multifragmentation mass spectrometry. Kinetic analysis, structure elucidation, matrix variation, radical scavenging...
The fluoroquinolones ciprofloxacin, danofloxacin, enoxacin, levofloxacin and lomefloxacin, occur in water bodies worldwide therefore pose a threat to the aquatic environment. Advanced purification procedures, such as electrochemical oxidation, may act remedy since they contribute eliminating contaminants prevent micropollutants from entering open bodies. By treatment micro-flow reactor equipped with boron-doped diamond (BDD) electrode, were efficiently degraded. A total of 15 new products...
This study focuses on the degradation of sulfonamide antibiotics, sulfadiazine, sulfamethazine, sulfamethoxazole, and sulfathiazole, using ultraviolet irradiation in various conditions. Different pHs were investigated combination with addition hydrogen peroxide further oxygen removal. High-performance liquid chromatography electrospray ionization ion-trap mass spectrometry was used to identify elucidate products establish concentration–time curves. Previously unknown could be characterized....
Fluorinated steroids were examined using 1D and 2D homo- heteronuclear (19)F NMR, such as (19)F-(1) H (19)F-(13)C. The utilization of fluorine NMR accounted for spectral simplification resulted in a straightforward pathway the determination structures including configuration these compounds; present an illustrative example other types fluorinated compounds, which are increasingly encountered drug discovery. potential is elaborated on detail two compounds containing diastereotopic fluorines...
Pharmaceuticals are found in waterbodies worldwide. Conventional sewage treatment plants often not able to eliminate these micropollutants. Hence, Advanced Oxidation Processes (AOPs) have been heavily investigated. Here, metoprolol is exposed UV irradiation, hydrogen peroxide, and ozonation. Degradation was analyzed using chemical kinetics both for initial secondary products. Photo-induced irradiation enhanced by peroxide addition accelerated degradation more than ozonation, leading complete...
Abstract Background Imidacloprid is among the most widely used insecticides and today found in surface ground water worldwide. It has been registered EU watchlist for monitoring. To prevent imidacloprid from entering bodies, advanced oxidation processes (AOP) have intensely researched. Photo-irradiation proved one of efficient methods to degrade eliminate anthropogenic micropollutants waters. The ecotoxicity assessment photoinduced degradation transformation products especially absence...
Process analytical technology aims at process knowledge and improvement, efficiency, sustainability. A prerequisite is monitoring. The combination of microreaction systems spectroscopy proved suitable due to dimension compound reduction real-time monitoring capabilities. Compact 1 H NMR, NIR, Raman were used monitor the biocatalyzed hydrolysis esterification acetic anhydride isoamyl acetate using immobilized Candida antarctica lipase B (CALB) in a system real-time. To facilitate...
<img src="http://www.aimspress.com/fileOther/PIC/environmental/05-05-372.jpg" alt="" /> Photolysis is currently being discussed and investigated as additional stage or at least part of an extended treatment for sustainable water purification in waste plants. This study describes the photoinduced degradation four macrolide antibiotics using UVC/VUV-irradiation. Special attention was paid to determination ecotoxicity formed products. To this purpose, MIC values were determined QSAR analysis...
<img src="file:///C:/Users/Administrator/Desktop/Doc1.mht" alt="" /><img src="https://www.aimspress.com/fileOther/PIC/environmental/Environ-07-01-005.jpg" /><br /> The ubiquitous presence of pharmaceuticals in the aquatic environment is a worldwide problem today. Current analytical methods reveal ever more different water bodies. concentrations waters that are detectable reach nano-and picogram ranges, i.e., ppb and ppt levels. Observed amount to as high few micrograms. Among major entry...
Abstract The Covid-19 pandemic has affected the global population since 2019. rapid development and approval of vaccines brought relief. Yet, effective cures are still being researched. Even if situation may end, SARS-CoV-2 will remain and, thus, continued application drugs lead to emissions active ingredients into aquatic environment, as with other anthropogenic micropollutants. However, a general method for trace analysis antiviral is missing. To this purpose, favipiravir, remdesivir, its...
The Noell Conversion Process was developed to guarantee the safe disposal of sewage sludge and other waste materials by means thermal treatment, evenwith very strict emission standards. center piece this process is a pressurized entrained flow gasifier. reactin conditions in gasifier does not only suppresses formation dioxins furans, but also completely destroys any furans contained materials. Another advantage referring treatment recovery marketable substances such as synthesis gas, sulphur...
Abstract Indirect and unsymmetrical indirect covariance NMR provide powerful tools to compute visualize correlation information by transforming component spectra into combined spectral data matrices. Sensitive such as TOCSY, HSQC NOESY can be quickly converted experimentally insensitive or time‐consuming HSQC‐NOESY. The comparison of illustrative series from four steroids, dexamethasone, testosterone, allylestrenol tibolone, renders the effects resonance overlap on ease interpretation...
Numerous studies have been reported on today’s ubiquitous presence of antibiotics in surface waters causing the emergence multidrug-resistant bacteria. Advanced water treatment procedures aim at complete prevention and elimination from entering natural bodies. In this study, photoinduced degradation processes using UVC-irradiation were applied toward selected fluoroquinolone, tetracycline, macrolide, sulfonamide antibiotics. Photodegradation products elucidated high-performance liquid...
A handheld Raman spectrometer was used to determine the ripeness of peppers. spectra were recorded non-invasively on fruit surface. The spectroscopic data transformed into a classification scheme referred as maturity index which allowed for attribution stadium four levels from immature fully mature. Hot pepper and tomato ripening includes pectic polysaccharide depolymerization, chlorophyll degradation carotenoid formation, among others. latter followed by spectroscopy. Two portable systems...
The fluoroquinolone ciprofloxacin occurs worldwide in the aquatic environment and has therefore been listed on 3rd European union watchlist for monitoring. To eliminate sewage wastewater treatment plants as entry pathways, advanced oxidation processes have intensely researched. Hence, photolysis at different pH ranges was studied its capacity to eradicate ciprofloxacin. High-performance liquid chromatography coupled high-resolution mass spectrometry used identify degradation products monitor...
The degradation of spiramycin induced by ultraviolet (UV) irradiation was studied at pH 3–4, 6–7 and 8–9 using high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry. Furthermore, the influence hydrogen peroxide oxygen on photodegradation investigated. Three products were observed in presence four absence oxygen. kinetics monitored as area-time curves, analyzed described subsequent follow-up reaction first-order models. m/z values...