A5090524034- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 diagnosis using AI
- Vaccine Coverage and Hesitancy
- Chronic Myeloid Leukemia Treatments
- COVID-19 and healthcare impacts
- Multiple Myeloma Research and Treatments
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- Viral Infections and Immunology Research
- Viral Infections and Outbreaks Research
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- interferon and immune responses
- Dementia and Cognitive Impairment Research
- vaccines and immunoinformatics approaches
- HIV/AIDS drug development and treatment
- Optimism, Hope, and Well-being
Nference (United States)
2020-2023
Mayo Clinic
2023
IQVIA (France)
2019
The hand of molecular mimicry in shaping SARS-CoV-2 evolution and immune evasion remains to be deciphered. Here, we report 33 distinct 8-mer/9-mer peptides that are identical between the human reference proteome. We benchmark this observation against other viral-human peptide identity, which suggests generally similar extents for many viruses. Interestingly, 20 novel mimicked by have not been observed any previous coronavirus strains (HCoV, SARS-CoV, MERS). Furthermore, four map onto...
Abstract Understanding the relationships between pre-existing conditions and complications of COVID-19 infection is critical to identifying which patients will develop severe disease. Here, we leverage ~1.1 million clinical notes from 1803 hospitalized deep neural network models characterize associations 21 development 20 (e.g. respiratory, cardiovascular, renal, hematologic) throughout course (i.e. 0–30 days, 31–60 61–90 days). Pleural effusion was most frequent complication early (89/1803...
PURPOSE: Median duration of daratumumab (DARA) administration for treatment multiple myeloma is 3-7 hours the intravenous formulation (DARA IV) and 3-5 minutes subcutaneous SC). Here, we describe clinical characteristics DARA using a novel method data extraction from electronic health records. METHODS: Time-based measurements were extracted scheduling/pharmacy software program that tracked patient movement through appointments patients initiating in Mayo Clinic infusion centers April 5,...
BackgroundConsecutive negative SARS-CoV-2 PCR test results are being considered to estimate viral clearance in COVID-19 patients. However, there anecdotal reports of hospitalization from protracted complications despite such confirmed clearance, presenting a clinical conundrum.MethodsWe conducted retrospective analysis 222 hospitalized patients compare those that were readmitted post-viral (hospitalized post-clearance cohort, n = 49) with not re-admitted (non-hospitalized 173) between...
Abstract As the COVID-19 vaccination campaign unfolds as one of most rapid and widespread in history, it is important to continuously assess real-world safety FDA-authorized vaccines. Curation from large-scale electronic health records (EHRs) allows for near real-time evaluations that were not previously possible. Here, we advance context- sentiment-aware deep neural networks over multi-state Mayo Clinic enterprise (Minnesota, Arizona, Florida, Wisconsin) automatically curating adverse...
Abstract The current diagnostic gold-standard for SARS-CoV-2 clearance from infected patients is two consecutive negative PCR test results. However, there are anecdotal reports of hospitalization protracted COVID complications despite such confirmed viral clearance, presenting a clinical conundrum. We conducted retrospective analysis 266 to compare those that were admitted/re-admitted post-viral ( hospitalized post-clearance cohort , n=93) with pre-clearance but not re-admitted...
Abstract Understanding the relationships between pre-existing conditions and complications of COVID-19 infection is critical to identifying which patients will develop severe disease. Here, we leverage 1.1 million clinical notes from 1,903 hospitalized deep neural network models characterize associations 21 development 20 (e.g. respiratory, cardiovascular, renal, hematologic) throughout course (i.e. 0-30 days, 31-60 61-90 days). Pleural effusion was most frequent complication early (23% 383...
The hand of molecular mimicry in shaping SARS-CoV-2 evolution and immune evasion remains to be deciphered. We identify 33 distinct 8-mer/9-mer peptides that are identical between human proteomes, along similar extents viral observed other viruses. Interestingly, 20 novel have not been any previous coronavirus (HCoV) strains. Four the total mimicked 8-mers/9-mers map onto HLA-B*40:01, HLA-B*40:02, HLA-B*35:01 binding from PAM, ANXA7, PGD, ALOX5AP proteins. This multiple proteins by is made...