Oxidative stress causes diverse neurological disorders. Parthanatos is a type of programmed cell death, characterised by strong activation poly (ADP-ribose) (PAR) polymerase-1 (PARP-1), PAR polymer accumulation, and nuclear translocation apoptosis-inducing factor (AIF), involved in cellular oxidative injury. Signalling c-Jun-N-terminal protein kinase (JNK) activated reactive oxygen species (ROS), this also contributes to ROS production. However, the exact relationship between JNK signalling...

Motility is important for virulence, biofilm formation, and the environmental adaptation of many bacteria. Vibrio parahaemolyticus (V. parahaemolyticus) contains two flagellar systems that are responsible motility, tightly regulated by transcription regulators sigma factors. In this study, we identified a novel factor, VPA1701, which regulates swarming motility V. parahaemolyticus. The VPA1701 deletion mutant (ΔVPA1701) eliminated on surface BHI agar plates reduced colonization in infant...

Lipids are vital biomolecules involved in the formation of various biofilms. Seizures can cause changes lipid metabolism brain. In-depth studies at multiple levels urgently needed to elucidate composition, distribution, and metabolic pathways brain after seizure. In this research, a cutting-edge targeted quantitative lipidomics study was conducted on hippocampal tissues six rats with temporal lobe epilepsy normal rats. Accurate quantification based linear equations calculated using an...

Stroke significantly impacts global health, being a primary cause of disability, dementia, and mortality. The interplay nutritional deficiency systemic inflammation plays pivotal role in determining stroke outcomes. While the Prognostic Nutritional Index (PNI) Advanced Lung Cancer Inflammation (ALI) have been recognized for their prognostic value various diseases, relevance prognosis necessitates further exploration. This study utilized data from National Health Nutrition Examination Survey...

Objectives: The present study explored the clinical characteristics and prognostic factors of epilepsy in patients with mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes (MELAS). Methods: Thirty-four MELAS were included study. They diagnosed by characteristics, genetic testing, muscle biopsy, retrospective analysis other data. divided into three groups according to effects treatment after at least 2 years follow-up. Results: Epilepsy was more common male than females...

It has been reported that sodium fluoride (NaF) suppresses the proliferation and induces apoptosis of chondrocytes. However, cellular molecular mechanisms effect have not elucidated. Therefore, aim this study was to evaluate effects NaF on primary cultured rat chondrocytes in vitro. Chondrocytes were treated with at concentrations 0, 1.5, 2.0, 2.5, 3.0, 3.5 4.0 mM. Cell viability decreased rate apoptotic cells increased significantly gradient concentration a time- dose-dependent manner....

Introduction The causal relationship between inflammatory factors and stroke subtypes remains unclear. This study aimed to analyze the 41 these two using Mendelian randomization (MR). Methods We performed a two-sample MR analysis assess effects of cytokines on its conducted genome-wide association (GWAS) data. inverse-variance weighted (IVW) method was adopted as main method, we series randomizations related sensitivity analyses. Results indicated some suggestive evidences: IVW approach,...

Vibrio parahaemolyticus can change their usual lifestyle of surviving in an aqueous environment attached to a host, wherein both swimming motility and swarming play important roles changes, respectively. VPA0041 is novel transcription factor involved regulating the ability V. parahaemolyticus. The deletion vpa0041 gene resulted loss brain heart infusion (BHI) agars, while was unaffected by VPA0041. Transmission electron microscope (TEM) assays showed that no flagellum found around bacterial...

To determine the effect of sodium-glucose cotransporter protein 2 (SGLT2) inhibition on ischemic stroke (IS) and investigate circulating proteins that mediate effects SGLT2 IS.

The poor sleep quality of epileptic patients may be partly due to the occurrence epileptiform discharges (EDs). We observed number interictal in each stage and explored associations between EDs phases patients.Two hundred 182 healthy volunteers were enrolled current study. For all subjects, video electroencephalography (EEG) monitoring 24-hr night polysomnography conducted detect analyze structures.EDs detected 91% with most frequent cases from temporal lobe. during waking, sleeping, or both...

Recurrent cerebral infarctions are extremely rare in patients with primary Sjögren syndrome. We report a 66-year-old woman who was admitted to our hospital due acute infarction exacerbation of dysphagia and right-sided hemiplegia as the main symptoms. In past 3 months, she had developed twice, even though no risk factors for atherosclerosis. She eventually diagnosed syndrome based on long history dryness eyes mouth, positive anti-Ro(SSA) antibodies, findings labial salivary gland biopsy. The...

We report one Chinese patient with neurosyphilis exhibiting periodic lateralized epileptiform discharges (PLEDs) in the electroencephalogram (EEG). The (male, 59 years old) manifested progressive cognitive decline and abnormal behavior. After several days, he gradually lost contact others, fell into a coma. EEG revealed waves, predominantly located right anterior frontal region. serum cerebrospinal fluid Venereal Disease Research Laboratory test Treponema pallidum hemagglutination assay were...

In order to get the method for improving salt resistance of Lycium ruthenium seeds and seedlings under NaCl stress, seed germination physiological characteristics L. was studied.Several indexes such as rate (Gr), vigor (Gv), index (Gi), (Vi), relative damage were measured. Other like water contents (RWC) , chlorophyll contents, soluble protein electrolyte leakage, malondialdehyde (MDA), peroxidase (POD) also measured.NaCl at lower concentration could promote but inhibit higher concentration....

Leukodystrophies are hereditary white matter diseases characterized by genetic polymorphisms and considerable phenotypic variability. They can be classified into myelin non-myelin malformations. These rare, affecting 1 out of 250,000-500,000 individuals manifest at any age. A subtype leukodystrophy, associated with missense mutations in the RNA polymerase subunit III (POLR3A) gene, is inherited an autosomal recessive manner.We report analyse a case 34-year-old female who presented ataxia....

BACKGROUNDSjögren syndrome (SS) is a chronic and systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands.And histoplasmosis an invasive mycosis caused saprophytic dimorphic fungus H. capsulatum.In patients with primary SS (PSS), disseminated (DH) extremely rare. CASE SUMMARYWe report 37-year-old female patient admitted to our hospital exacerbating fatigue, somnolence, pancytopenia as main symptoms.She was eventually diagnosed DH based on pancytopenia,...