A5039690039- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- Chromosomal and Genetic Variations
- Animal Behavior and Reproduction
- Insect and Arachnid Ecology and Behavior
- Neurobiology and Insect Physiology Research
- Autism Spectrum Disorder Research
- Pancreatic function and diabetes
Harvard University
2021
University of Pennsylvania
2015-2017
Fragile X syndrome (FXS) is an undertreated neurodevelopmental disorder characterized by low intelligence quotent and a wide range of other symptoms including disordered sleep autism. Although FXS the most prevalent inherited cause intellectual disability, its mechanistic underpinnings are not well understood. Using Drosophila as model FXS, we showed that select expression dfmr1 in insulin-producing cells (IPCs) brain was sufficient to restore normal circadian behavior rescue memory deficits...
Fragile X Syndrome (FXS), the most prevalent form of inherited intellectual disability and foremost monogenetic cause autism, is caused by loss expression FMR1 gene . Here, we show that dfmr1 modulates global metabolome in Drosophila. Despite our previous discovery increased brain insulin signaling, results indicate mutants have reduced carbohydrate lipid stores are hypersensitive to starvation stress. The observed metabolic deficits cannot be explained feeding behavior, as report...
Many animal species show aggression to gain mating partners and protect territories other resources from competitors. Both male female fruit flies of the Drosophila melanogaster exhibit in same-sex pairings, but strategies used are sexually dimorphic. We have begun explore biological basis for differing strategies, cues promoting one form over other. Here, we describe a line genetically masculinized females that switch between patterns based on sexual identity their opponents. When these...