A5083248466- MicroRNA in disease regulation
- Bacillus and Francisella bacterial research
- SARS-CoV-2 and COVID-19 Research
- Noise Effects and Management
- Salivary Gland Tumors Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Immunotherapy and Immune Responses
- Planarian Biology and Electrostimulation
- Eosinophilic Disorders and Syndromes
- interferon and immune responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Bacteriophages and microbial interactions
- Cancer-related molecular mechanisms research
- Connexins and lens biology
- Sinusitis and nasal conditions
- Extracellular vesicles in disease
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Ocular Surface and Contact Lens
- Lymphatic System and Diseases
- Nasolacrimal Duct Obstruction Treatments
- RNA Research and Splicing
- Lymphoma Diagnosis and Treatment
University of York
2017-2020
Hull York Medical School
2015-2017
University of Arkansas for Medical Sciences
2004
Center for Biologics Evaluation and Research
1996
Georgetown University
1990
Myelofibrosis is a severe myeloproliferative neoplasm characterized by increased numbers of abnormal bone marrow megakaryocytes that induce fibrosis, destroying the hematopoietic microenvironment. To determine cellular and molecular basis for aberrant megakaryopoiesis in myelofibrosis, we performed single-cell transcriptome profiling 135,929 CD34+ lineage− stem progenitor cells (HSPCs), proteomics, genomics, functional assays. We identified bias toward megakaryocyte differentiation apparent...
Intraperitoneal or intravenous infection of mice with Francisella tularensis LVS is lethal, an intraperitoneal 50% lethal dose (LD50) approaching a single bacterium. Intradermal (i.d.) has much higher LD50, about 10(6) bacteria in BALB/cByJ mice, and survival i.d. leads to solid generation immunity against challenge. To define the minimal requirements for both initial long-term infection, we characterized nature lymphocyte-deficient BALB/cByJ.scid (scid) mice. scid infected strain survived...
Normal mice readily survive a sublethal intradermal (i.d.) infection with Francisella tularensis live vaccine strain (LVS), model intracellular bacterium, and are strongly protected against subsequent lethal challenge. However, athymic nu/nu mice, which lack mature alphabeta TCR+ T lymphocytes, succumb to i.d. within 30 days. Here we characterize the cell subpopulations necessary for both resolution of generation optimal protective immunity LVS. BALB/cByJ treated anti-CD4 or anti-CD8 Abs...
The abundance of miR-132 ranges from constitutively high in the brain where it is necessary for neuronal development and function, to inducible expression haematopoietic endothelial cells controls angiogenesis immune activation. We show that AGO2, a protein central miRNA-mediated gene silencing miRNA biogenesis, negatively regulated by miR-132. Using HeLa cells, we demonstrate interacts with AGO2 mRNA 3'UTR suppresses AGO2-dependent small RNA-mediated silencing. Similarly, over-expression...