A5033315315- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Nanoplatforms for cancer theranostics
- Spectroscopy and Laser Applications
- Advanced Photocatalysis Techniques
- Luminescence and Fluorescent Materials
- Laser-induced spectroscopy and plasma
- Laser Design and Applications
- Atomic and Molecular Physics
- Catalysis and Oxidation Reactions
- Photochemistry and Electron Transfer Studies
- Nanocluster Synthesis and Applications
- Inorganic Chemistry and Materials
- Advanced Chemical Physics Studies
- Analytical Chemistry and Sensors
- Atmospheric chemistry and aerosols
- Mass Spectrometry Techniques and Applications
- Layered Double Hydroxides Synthesis and Applications
- Carbon and Quantum Dots Applications
- Organometallic Complex Synthesis and Catalysis
- Molecular Sensors and Ion Detection
- Catalytic Processes in Materials Science
- Atmospheric and Environmental Gas Dynamics
Czech Academy of Sciences, J. Heyrovský Institute of Physical Chemistry
2016-2025
Czech Academy of Sciences
2008-2021
Nemocnice Znojmo
2020
Havlíčkův Brod Hospital
1997-2019
VSB - Technical University of Ostrava
2009-2015
Czech Academy of Sciences, Institute of Thermomechanics
2015
Charles University
2010
Czech Academy of Sciences, Institute of Inorganic Chemistry
2002-2010
Université de Lille
2009
Centre National de la Recherche Scientifique
2009
Newly synthesized zinc phthalocyanine bearing sixteen quaternized imidazolyl moieties on the periphery displays high water-solubility, lack of aggregation and singlet oxygen quantum yield in water (ΦΔ > 0.33). The vitro tests indicated excellent anticancer photodynamic activity (EC50 = 36.7 nM) low dark toxicity to non-cancerous cells (TC50 395 μM).
Development of new types antibacterial coatings or nanocomposites is great importance due to widespread multidrug-resistant infections including bacterial infections. Herein, we investigated biocompatibility as well structural, photocatalytic, and properties photoactive hydrophobic carbon quantum dots/polyurethane nanocomposite. The swell-encapsulation-shrink method was applied for production these nanocomposites. Hydrophobic were found be highly effective generator singlet oxygen upon...
Abstract A new Mo 6 cluster complex and its silica polyurethane composites have been synthesized characterized. These materials are highly luminescent with emission above 650 nm, produce singlet oxygen high efficiency, photostable, can be excited up to 580 nm. properties desirable for the construction of probes oxygen, photoactive oxidation reactions easily separable active carriers, bactericidal textile surfaces upon daylight irradiation.
The excited-state dynamics, luminescence, and redox properties of a series hexanuclear molybdenum cluster complexes, (nBu4N)2[Mo6X14] (nBu4N)2[Mo6X8(CF3COO)6] (X = Cl, Br, or I), were investigated. Substitution the apical halogen ligands for trifluoroacetate increased oxidation potentials induced blue shift in absorption luminescence bands as well considerable increase quantum yields heavy inner ligands. Time-resolved transient measurements showed that intersystem crossing from excited...
Inimitable properties of carbon quantum dots as well a cheap production contribute to their possible application in biomedicine especially antibacterial and antibiofouling coatings. Fluorescent hydrophobic are synthesized by bottom-up condensation method used for deposition uniform homogeneous Langmuir–Blodgett thin films on different substrates. It is found that this kind generates singlet oxygen under blue light irradiation. Antibacterial testing four bacteria strains (Escherichia coli,...
Microbial colonization of biomedical devices is a recognized complication contributing to healthcare-associated infections. One the possible approaches prevent surfaces from biofilm formation antimicrobial photodynamic inactivation based on cytotoxic effect singlet oxygen, O2(1Δg), short-lived, highly oxidative species, produced by energy transfer between excited photosensitizers and molecular oxygen. We synthesized porphyrin-based covalent organic frameworks (COFs) Schiff-base chemistry....
Newly synthesized octahedral molybdenum cluster compound (n-Bu4N)2[Mo6I8(OOC-1-adamantane)6] revealed uncharted features applicable for the development of X-ray inducible luminescent materials and sensitizers singlet oxygen, O2((1)Δg). The exhibits a red-NIR luminescence in solid state solution (e.g., quantum yield 0.76 tetrahydrofuran) upon excitation by UV-vis light. originating from excited triplet states is quenched molecular oxygen to produce O2((1)Δg) with high yield. Irradiation...
A series of luminescent octahedral molybdenum cluster complexes were obtained by treating Na2[Mo6I8(OMe)6] with icosahedral closo-dicarbaborane C-carboxylic acids in refluxing tetrahydrofuran. The study the photophysical properties Na2[Mo6I8(1-OOC-1,2-closo-C2B10H11)6] (1), Na2[Mo6I8(1-OOC-1,7-closo-C2B10H11)6] (2), and Na2[Mo6I8(1-OOC-1,12-closo-C2B10H11)6] (3) acetonitrile revealed a red luminescence high quantum yields up to 0.93 for 2, an efficient quenching oxygen, singlet oxygen...
Polystyrene ion-exchange nanofiber materials with large surface areas and adsorption capacities were prepared by electrospinning followed the sulfonation of a cationic 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP) photosensitizer on surfaces. The morphology, structure, photophysical properties these characterized microscopic methods steady-state time-resolved fluorescence absorption spectroscopies. externally bound TMPyP can be excited visible light to form triplet states...
Rare-earth layered hydroxides with intercalated tetrasulfonated porphyrins and corresponding to the chemical formula Ln2(OH)4.7(Por)0.33·2H2O (Ln = Eu3+, Tb3+; Por 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin (TPPS) PdTPPS) have been prepared investigate their photophysical properties. A slight variation of synthetic procedure led metal–organic framework (MOF) assembled from a distorted octahedral oxometalate clusters [Eu6(μ6-O)(μ3-OH)8(H2O)14]8+. These secondary building units (SBUs) are...
The photocytotoxic activity of porphyrin-containing materials including metal-organic frameworks (MOFs) has attracted ever increasing interest. We have developed a simple synthesis hexagonal PCN-222/MOF-545 nanoparticles, which are powerful in inducing reactive oxygen species-mediated apoptosis cancer cells upon visible light irradiation. extent the cytotoxic effect well correlates with nanoparticle size and structural instability. High phototoxicity presented nanoparticles their...
The maintenance of an aseptic environment for chronic wounds is one the most challenging tasks in wound-healing process. Furthermore, emergence antibiotic-resistant bacterial strains on rise, rendering conventional treatments less effective. A new antibacterial material consisting a polyurethane Tecophilic(™) nanofibre textile (NT) that was prepared by electrospinning and doped tetraphenylporphyrin (TPP) photosensitizer activated visible light tested use wound beds bandages. In vitro...
The surfaces of electrospun polystyrene (PS) nanofiber materials with encapsulated 1% w/w 5,10,15,20-tetraphenylporphyrin (TPP) photosensitizer were modified through sulfonation, radio frequency (RF) oxygen plasma treatment, and polydopamine coating. exhibited efficient photogeneration singlet oxygen. postprocessing modifications strongly increased the wettability pristine hydrophobic PS nanofibers without causing damage to nanofibers, leakage photosensitizer, or any substantial change in...
A nanocrystalline TiO2 (anatase) nanosheet exposing mainly the (001) crystal faces was tested as photoanode material in dye-sensitized solar cells. The nanosheets were prepared by hydrothermal growth HF medium. Good-quality thin films deposited on F-doped SnO2 support from suspension ethanolic or aqueous media. anatase face adsorbs a smaller amount of used dye sensitizer (C101) per unit area than (101) which reference. corresponding cell with sensitized (001)-nanosheet exhibits larger...
Octahedral rhenium cluster complexes have recently emerged as relevant building blocks for the design of singlet oxygen photosensitizing materials toward biological applications such blue-light photodynamic therapy. However, their generation ability well properties been studied only superficially. Herein we investigate in detail photogeneration, dark and photoinduced cytotoxicity, cellular uptake kinetics, localization vitro oxidative stress, cytotoxicity series octahedral [{Re6Q8}(CN)6]4-,...
Development of new types antimicrobial coatings is utmost importance due to increasing problems with pathogen transmission from various infectious surfaces human beings. In this study, highly potent polyurethane composite films encapsulated by hydrophobic riboflavin-based carbon polymer dots are presented. Detailed structural, optical, antimicrobial, and cytotoxic investigations these composites were conducted. Low-power blue light triggered the eradicate Escherichia coli in 30 min, whereas...
The syntheses and aggregation properties of novel cationic meso-tetraphenylporphyrins substituted in the para-positions with -CH2(pyridinio)+ (P11), -CH2N+(CH3)3 (P22), -CH2P+(n-butyl)3 (P33), -CH2P+(phenyl)3 (P44), -CH2S+(CH3)2 (P55) -CH2SC(NH2)2+ (P66) groups are described. Their use as photosensitizers their interactions DNA nucleotides were studied by optical methods compared those anionic meso-tetrakis(4-sulfonatophenyl)porphyrin (TPPS) meso-tetrakis(4-N-methylpyridyl)porphyrin (TMPyP)....
We present novel photofunctional nanofabrics that produce singlet oxygen on irradiation and have a bactericidal effect.
The interaction between self-aggregated porphyrins such as 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin (TPPS) and 5,10,15,20-tetrakis(4-phosphonatophenyl)porphyrin (TPPP), a generation 5 (G5) PAMAM dendrimer template is governed by minute differences of porphyrin acido-basic properties. While at neutral pH both monomeric TPPS TPPP form complexes with G5, decreasing did not lead to ring protonation (pK(a) approximately 5) but rather the preferential formation H-aggregates (probably...
Polyurethane (PUR) nanofabrics based on nanofibers of average diameters in the range 250-110 nm with different meso-tetraphenylporphyrin (TPP) loading (0.01-5 wt %) were prepared by an electrospinning process. The oxygen quenching excited states and singlet oxygen-sensitized delayed fluorescence (SODF) TPP studied at pressures. We found that PUR matrix is present monomeric state, it easily accessed oxygen. Analysis kinetics triplet, oxygen, SODF indicates repopulation fluorescent state...