A5100400495- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Venous Thromboembolism Diagnosis and Management
- Peptidase Inhibition and Analysis
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Dysphagia Assessment and Management
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Epigenetics and DNA Methylation
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Pleural and Pulmonary Diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Cancer therapeutics and mechanisms
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
University of Science and Technology of China
2022-2024
Sun Yat-sen University
2024
Hefei Institutes of Physical Science
2022-2024
Chinese Academy of Sciences
2022-2024
Affiliated Hospital of Southwest Medical University
2022-2024
Anhui Provincial Hospital
2022
MET exon 14 skipping mutation (METex14m) is rare and occurs in approximately 1-4% of all non-small cell lung cancer (NSCLC) patients 2.8% resected stage I-III NSCLC patients. Savolitinib an oral, potent highly selective type Ib inhibitor, which has been shown to be promising activity acceptable safety profile with advanced harboring METex14m. Most recently, many studies have probing into the feasibility efficacy target therapy for perioperative application NSCLC. Interestingly, there are...
Abstract Background Tuberculosis (TB) is a chronic infectious disease caused by the Mycobacterium tuberculosis complex (MTBC), which leading cause of death from diseases. The rapid and accurate microbiological detection MTBC crucial for diagnosis treatment TB. Metagenomic next-generation sequencing (mNGS) has been shown to be promising satisfying application in However, relevant research about difference mNGS between bronchoalveolar lavage fluid (BALF) lung biopsy tissue specimens remains...
A 43-year-old man presented with weakness in his right upper limb for 2 months. Head MRI showed intracranial multiple abnormal signal foci. Malignancy was suspected. The patient subsequently enrolled the clinical trial of 68Ga-FAPI PET/CT. PET/CT FAPI-avid It also highly suggestive malignancy. However, combination manifestations, imaging findings, cerebral spinal fluid examinations, and effective immunotherapy confirmed diagnosis progressive multifocal leukoencephalopathy. may have potential...
Family with sequence similarity 83, member A (FAM83A) plays an essential and fundamental role in the proliferation, progression, apoptosis of many malignant tumors, including lung cancer. This study aimed to determine expression pattern FAM83A adenocarcinoma (LUAD) its correlation prognosis cancer survival patients. Bioinformatics analysis, immunohistochemistry, Western blotting were used explore detect LUAD cells. The mechanism proliferation migration was examined. between rate assessed by...
Abstract Background Small cell lung cancer (SCLC) is a very malignant tumor with rapid growth and early metastasis. Platinum-based chemo-resistance the major issue for SCLC treatment failure. Identifying new prognostic model will help to make an accurate decision patients. Methods Using genomics of drug sensitivity in (GDSC) database, we identified cisplatin resistance-related lncRNAs cells. Based on competing endogenous RNA (ceRNA) network, mRNAs correlated lncRNAs. Cox LASSO regression...
Current clinical guidelines limit surgical intervention to patients with cT1-2N0M0 small cell lung cancer (SCLC). Our objective was reassess the role of surgery in SCLC management, and explore novel prognostic indicators for surgically resected SCLC. We reviewed all diagnosed from January 2011 April 2021 our institution. Survival analysis conducted using Kaplan-Meier method, independent factors were assessed through Cox proportional hazard model. In addition, immunohistochemistry (IHC)...
Platinum-based chemo-resistance is the major issue for treatment of small cell lung cancer (SCLC). The integrative analysis multi-omics data a reliable approach discovering novel biomarkers associated with chemo-resistance. Here, and Cox regression found that higher expression PCDHB4 was poorer survival SCLC patients who received chemotherapy. gene hypomethylated upregulated in SCLC, which validated levels promoter methylation, mRNA, protein expression. Mechanistically, using bulk RNA-seq...
Early and timely closure of secondary tracheoesophageal fistula (TEF) is crucial for critically ill patients. For those requiring invasive mechanical ventilation, the Amplatzer Duct Occluder II (ADO II) can be used as an emergency therapeutic option to rapidly close TEF, providing opportunities subsequent treatments.
We aimed to investigate the association between critical perfusion delay and poor outcome among recanalized stroke patients with anterior large-vessel occlusion, use pretreatment hypoperfusion biomarkers on CT predict futile recanalization even after successful thrombectomy.
<title>Abstract</title> Background and Purpose We aimed to investigate the association between critical perfusion delay poor outcome among recanalized stroke patients with anterior large-vessel occlusion, use pretreatment hypoperfusion biomarkers on CT predict futile recanalization even after successful thrombectomy. Methods An ischemic region time-to-maximum (Tmax) > 12s or 10s was defined as hypoperfusion, Tmax 8s moderate intensity ratio (HIR, volumetric of / 6s) represented for...