A5091770540- Shoulder and Clavicle Injuries
- Shoulder Injury and Treatment
- Ubiquitin and proteasome pathways
- Musculoskeletal pain and rehabilitation
- Trauma Management and Diagnosis
- Protein Degradation and Inhibitors
- Genomics and Chromatin Dynamics
Exactech (United States)
2019
University of South Florida
2018
Timely stalling and resumption of RNA polymerases at damaged chromatin are actively regulated processes. Prior work showed an importance FACT histone chaperone in such process. Here we provide a new role OTUD5 deubiquitinase the FACT-dependent Through DUB RNAi screen, found as specific stabilizer UBR5 E3 ligase. localizes to DNA double strand breaks (DSBs), interacts with represses Pol II elongation synthesis. co-localizes component SPT16 antagonizes H2A deposition DSB lesions. independently...
Little guidance exists regarding the minimum screw length and quantity necessary to achieve fixation in reverse total shoulder arthroplasty (rTSA); that end, this study quantified displacement of 2 different sizes glenoid baseplates using multiple lengths quantities screws a low-density polyurethane bone-substitute model.Testing rTSA loosening was conducted according ASTM F 2028-17. To independently evaluate impact on for baseplates, were constructed screws, 4 or 6 (with latter being used...