A5069431455- Cassava research and cyanide
- Isotope Analysis in Ecology
- PARP inhibition in cancer therapy
- Plant Virus Research Studies
- Inflammasome and immune disorders
- RNA and protein synthesis mechanisms
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Marine Toxins and Detection Methods
University of California, San Diego
2022-2025
Hosts have evolved diverse strategies to respond microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that 3CL protease (3CL pro ) encoded coronaviruses, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), cleaves a rapidly evolving region human CARD8 activates robust inflammasome response. is required for cell death release pro-inflammatory cytokines during SARS-CoV-2 infection. We...
Protein post-translational modifications (PTMs) are an important battleground in the evolutionary arms races that waged between host innate immune system and viruses. One such PTM, ADP-ribosylation, has recently emerged as mediator of antiviral immunity. Important for host–virus conflict over this PTM is addition ADP-ribose by PARP proteins removal macrodomain-containing proteins. Interestingly, several proteins, known macroPARPs, contain macrodomains well a domain, these both response...
Viral manipulation of posttranslational modifications (PTMs) is critical to enable control over host defenses. Evidence suggests that one such PTM, adenosine 5′-diphosphate (ADP)–ribosylation, important for viral replication, but the and components involved are poorly understood. Here, we demonstrate several human poly(ADP-ribose) polymerase (PARP) proteins, including zinc-finger domain containing PARP7 (TiPARP) PARP12, directly ADP-ribosylate alphaviral nonstructural proteins (nsPs), nsP3...
SUMMARY Amygdalin is a cyanogenic glycoside widely used by many plants in herbivore defense. Poisonous to most animals, amygdalin-derived cyanide detoxified potent enzymes commonly found bacteria and but not animals. Here we show that the nematode C. elegans can detoxify amygdalin genetic pathway comprising cysl-1, egl-9, hif-1 cysl-2 . Essential for resistance, cysl-1 encodes protein similar cysteine synthetic plants, functionally co-opted We identify exclusively HIF-activating egl-9...
Amygdalin is a cyanogenic glycoside widely used by many plants in herbivore defense. Poisonous to most animals, amygdalin-derived cyanide detoxified potent enzymes commonly found bacteria and but not animals. Here we show that the nematode C. Elegans can detoxify amygdalin genetic pathway comprising cysl-1, egl-9,hif-1 cysl-2. Essential for resistance, cysl-1 encodes protein similar cysteine synthetic plants, functionally co-opted Elegans. We identify exclusively HIF-activating egl-9...