A5032329087- Genomics and Phylogenetic Studies
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Genetic diversity and population structure
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Antimicrobial Resistance in Staphylococcus
- Music History and Culture
- Cancer-related molecular mechanisms research
- Theater, Performance, and Music History
- Ocular Infections and Treatments
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Chromosomal and Genetic Variations
- RNA and protein synthesis mechanisms
- Amphibian and Reptile Biology
Wellcome Sanger Institute
2025
Massachusetts Eye and Ear Infirmary
2022-2024
Harvard University
2022-2024
Harvard University Press
2024
Columbia University
2019
ABSTRACT Bacterial keratitis is a vision-threatening infection mainly caused by Gram-positive bacteria (GPB). Antimicrobial therapy commonly empirical using broad-spectrum agents with efficacy increasingly compromised the emergence of antimicrobial resistance. We used combination phenotypic tests and genome sequencing to identify predominant lineages GPB causing characterize their resistance patterns. A total 161 isolates, including Staphylococcus aureus ( n = 86), coagulase-negative...
Streptococcus pneumoniae is a leading cause of ocular infections including serious and sight-threatening conditions. The use pneumococcal conjugate vaccines (PCV) has substantially reduced the incidence pneumonia invasive diseases, but had limited impact on infections. Additionally, widespread vaccine resulted in ongoing selective pressure serotype replacement carriage disease. To gain insight into population structure isolates causing post-PCV-13 time period, we investigated genomic...
The major histocompatibility complex (MHC) is an important genomic region for adaptive immunity and has long been studied in ecological evolutionary contexts, such as disease resistance mate kin selection. MHC investigated extensively mammals birds but far less so squamate reptiles, the third radiation of amniotes. We localized core two species, green anole (Anolis carolinensis) brown (A. sagrei), provide first detailed characterization MHC, including presence ordering known genes these...
Abstract Stew (born Mark Stewart) is a punk rocker and musical theater writer performer. This profile combines new interviews of with an analysis his Tony Award-winning Passing Strange , which was recently revived in the West End, to illuminate how rock music-inspired persona influences approach creating musicals.