Extinction-resistant fear is considered to be a central feature of pathological anxiety. Here we sought determine if individual differences in Intolerance Uncertainty (IU), potential risk factor for anxiety disorders, underlies compromised extinction. We tested this hypothesis by recording electrodermal activity 38 healthy participants during acquisition and assessed the temporality extinction, examining early late extinction learning. During low IU was associated with larger skin...

Coordination of activity between the amygdala and ventromedial prefrontal cortex (vmPFC) is important for fear-extinction learning. Aberrant recruitment this circuitry associated with anxiety disorders. Here, we sought to determine if individual differences in future threat uncertainty sensitivity, a potential risk factor disorders, underly compromised fear extinction circuitry. Twenty-two healthy subjects completed cued conditioning task acquisition phases. During task, pupil dilation, skin...

Attending to stimuli that share perceptual similarity learned threats is an adaptive strategy. However, prolonged threat generalization cues signalling safety considered a core feature of pathological anxiety. One potential factor may sustain over-generalization sensitivity future uncertainty. To assess the extent which Intolerance Uncertainty (IU) predicts generalization, we recorded skin conductance in 54 healthy participants during associative learning paradigm, where and varied...

Abstract Intolerance of uncertainty (IU) is a transdiagnostic risk factor for internalizing disorders. Prior work has found that IU may be associated with either increased reactivity to threat or, alternatively, decreased differential responding between and nonthreat/safety cues (i.e., generalization). For example, by Morriss, Macdonald, & van Reekum (2016) higher was generalization during acquisition (using skin conductance response (SCR)), as well less differentiation extinction...

Intolerance of uncertainty (IU), the tendency to find distressing, is an important transdiagnostic dimension in mental health disorders. Higher self-reported IU has been linked poorer threat extinction training (i.e., updating safe associations), a key process that targeted exposure-based therapies. However, it remains be seen whether IU-related effects during are reliably and specifically driven by construct or particular subcomponent over other measures anxiety. A meta-analysis studies...

Uncertainty and emotion are an inevitable part of everyday life play a vital role in mental health. Yet, our understanding how uncertainty interact is limited. Here, online survey was conducted (n = 231) to examine whether evokes modulates range negative positive emotions. The data show that predominantly associated with emotional states such as fear/anxiety. However, also found modulate variety other (i.e., sadness/upset, anger/frustration, confusion) surprise/interest excited/enthusiastic)...

Individuals high in self-reported Intolerance of Uncertainty (IU) tend to view uncertainty as unbearable and stressful. Notably, IU is transdiagnostic, levels are observed across many different emotional disorders (e.g., anxiety, depression). Research has primarily focused on how evokes modulates states such fear anxiety. However, recent research suggests that may have relevance for a broader range states. Here, an online survey was conducted examine whether negative fear/anxiety,...

Intolerance of uncertainty (IU) is associated with difficulty in updating contingencies from threatening to safe during extinction learning. However, it unknown whether high IU individuals have (1) generally threat associations when change or (2) specifically learning, where direct omitted. To address this question, we recorded IU, expectancy ratings, and skin conductance 44 healthy participants an associative learning paradigm, safety were reversed. During acquisition reversal, observed...

Abstract Heightened physiological responses to uncertainty are a common hallmark of anxiety disorders. Many separate studies have examined the relationship between individual differences in intolerance (IU) and during different contexts. Despite this, there is scarcity research examining extent which IU related shared or discrete patterns anticipatory responding across Anticipatory were assessed three contexts (associative threat learning extinction, uncertainty, decision‐making) within same...

Attentional bias to uncertain threat is associated with anxiety disorders. Here we examine the extent which emotional face distractors (happy, angry and neutral) individual differences in intolerance of uncertainty (IU), impact saccades two versions "follow a cross" task. In both follow cross task, probability receiving an distractor was 66.7%. To increase perceived regarding location distractors, one tasks additional non-predictive cues were presented before onset target. We did not find IU...