A5073950771- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Click Chemistry and Applications
- Protein Structure and Dynamics
- Enzyme Structure and Function
- Nerve injury and regeneration
- Pharmacy and Medical Practices
- Conducting polymers and applications
- RNA Interference and Gene Delivery
- Pineapple and bromelain studies
- Cerebrovascular and genetic disorders
- Advanced Glycation End Products research
- Bioinformatics and Genomic Networks
- Oral microbiology and periodontitis research
- Bone and Dental Protein Studies
- Neurological Disorders and Treatments
- Ginkgo biloba and Cashew Applications
- Polysaccharides and Plant Cell Walls
- Wnt/β-catenin signaling in development and cancer
- Chemical Synthesis and Analysis
Emory University
2023-2025
Indian Institute of Technology Gandhinagar
2019-2022
Alzheimer's disease (AD) is a complex neurodegenerative disorder that develops over decades. AD brain proteomics reveals vast alterations in protein levels and numerous altered biologic pathways. Here, we compare proteome network changes with the proteomes of amyloid β (Aβ)-depositing mice to identify conserved divergent networks identifying an Aβ responsome. Proteins most (M42) accumulate plaques, cerebrovascular (CAA), and/or dystrophic neuronal processes, overexpression two M42 proteins,...
Abstract Alzheimer’s disease (AD) is characterized by significant clinical and molecular heterogeneity, influenced genetic demographic factors. Using an unbiased, network-driven approach, we analyzed the cerebrospinal fluid (CSF) proteome from 431 individuals (483 samples), including 111 African American participants, to identify core protein modules associated with AD, race, sex, age. Our analysis revealed ten co-expression linked distinct biological pathways cell types, many of which...
Abstract We report a highly significant correlation between human Alzheimer’s disease (AD) brain proteome changes and those in CRND8 APP695NL/F transgenic mice. Comparing protein observed the mice with co-expression networks derived from (AD), reveals both conserved divergent module changes. Many proteins most (M42, matrisome) accumulate plaques, cerebrovascular amyloid (CAA), dystrophic neuronal processes, or combination thereof. Overexpression of two M42 proteins, midkine (Mdk)...
Cellulase containing nanobiocatalysts have been useful as an extraction tool based on their ability to disrupt plant cell walls. In this work, we investigate the effect of nanoparticle composition and chemical linkage towards immobilized cellulase activity. nanoconstructs prepared, characterized compared for loading efficiencies with standard assays enzyme kinetics correlate well cognate efficiencies. Application cellulase-immobilized nanoparticles onion skins results in release a...
Tau protein is found abundantly in neurofibrillary tangles Alzheimer's disease (AD). The longest human tau isoform (2N4R) has 44 lysine residues. Several lysine-based post-translational modifications (PTMs) such as glycation, acetylation, ubiquitination, and sumoylation have been implicated not only AD, but also other tauopathies. Carbamylation one neutralizing age-related nonenzymatic PTM which can modulate the aggregation propensity of tau. In this work, we studied potential lysine-rich...
Alpha-synuclein (α-Syn), an intrinsically disordered protein (IDP), is associated with neurodegenerative disorders, including Parkinson's disease (PD or other α-synucleinopathies. Recent investigations propose the transmission of α-Syn fibrils, in a prion-like manner, by entering proximal cells to seed further fibrillization PD. Despite recent advances, mechanisms which extracellular aggregates internalize into remain poorly understood. Using simple cell-based model human...
Triazole-based compounds as inhibitors and disaggregators of α-synuclein.
Abstract Background Recently, a highly significant brain proteome divergent modules change between Alzheimer’s disease (AD) and CRND8 APP 695NL/F transgenic mice has been found. The M42 module is the in human AD most correlated with amyloid tau pathologies cognitive decline. Among all proteins this module, (SPARC‐related modular calcium‐binding protein 1) SMOC1 emerging as robust biomarker of deposition CSF. It increases CSF parallel Ab42:40 ratios’ decrease. also markedly increased...