A5086690056- Peptidase Inhibition and Analysis
- Neuropeptides and Animal Physiology
- Ferrocene Chemistry and Applications
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Surface and Thin Film Phenomena
- Synthetic Organic Chemistry Methods
- Molecular Junctions and Nanostructures
- Estrogen and related hormone effects
- Protease and Inhibitor Mechanisms
- Drug Transport and Resistance Mechanisms
- Inflammatory mediators and NSAID effects
- Malaria Research and Control
- HIV/AIDS drug development and treatment
- Synthesis and Catalytic Reactions
- Radiopharmaceutical Chemistry and Applications
- Synthesis and Biological Evaluation
- Trypanosoma species research and implications
- Surface Chemistry and Catalysis
- Catalysis for Biomass Conversion
- Mesoporous Materials and Catalysis
- DNA and Nucleic Acid Chemistry
- Cyclopropane Reaction Mechanisms
- Graphene research and applications
- Nanowire Synthesis and Applications
Laboratoire d'innovation moléculaire et applications
2020
Centre National de la Recherche Scientifique
2003-2018
Université de Haute-Alsace
2005-2018
Université de Strasbourg
2018
Physique des interactions ioniques et moléculaires
2004-2013
Laboratoire de Chimie Organique
2005-2012
École Nationale Supérieure de Chimie de Montpellier
2006-2011
Chimie ParisTech
2003-2005
École nationale supérieure de chimie de Mulhouse
2005
Sorbonne Université
2005
A series of ruthenocene derivatives, 1-[4-(O(CH2)nN(CH3)2)phenyl]-1-(4-hydroxyphenyl)-2-ruthenocenylbut-1-ene, with n = 2−5, based on the structure breast cancer drug tamoxifen has been prepared. These compounds were obtained, via a McMurry cross-coupling reaction, as mixture Z and E isomers that could not be separated by HPLC. The relative binding affinity values for estrogen receptor α (ERα) 2 3 very high (85 53%) surpassed even hydroxytamoxifen (38.5%), active metabolite tamoxifen....
The electronic structure of cobalt-phthalocyanine (CoPc) molecules adsorbed on Ag(100) is investigated by photoemission spectroscopy. results are compared to first-principles calculations, based many-body perturbation theory in the GW approximation. data, obtained from both multilayer and monolayer films CoPc, show that charge transfer occurs between first molecular layer metal surface. Varying photon energy, tune photoionization cross sections, reveals charge-transfer-related interface...
Abstract A series of organometallic antiestrogens based on the OH‐tamoxifen (OH‐Tam) skeleton and bearing (η 5 ‐C H 4 )Re I (CO) 3 unit has been prepared by using McMurry coupling for purpose studying their biological behaviour. The cyclopentadienylrhenium tricarbonyl moiety is indeed stable in media, compact, lipophilic easy to handle. Furthermore, this study allowed us select best candidates subsequent use as radiopharmaceuticals either imaging or therapy appropriate radionucleides, namely...
[reaction: see text] Enantioselective deprotonation of 4-substituted cyclohexanones and highly stereoselective conjugate addition higher order mixed cuprates were the key steps in a concise synthesis fumagalone-related molecules. The origin (low) biological activity new compounds as compared to fumagalone is briefly discussed.
The synthesis of racemic substituted 7-amino-5,7,8,9-tetrahydrobenzocyclohepten-6-one hydrochlorides was optimized to enhance reproducibility and increase the overall yield. In order investigate their specificity, series enzyme inhibition assays were carried out against a diversity proteases, covering representative members aspartic, cysteine, metallo serine endopeptidases including eight monometallic M1 family aminopeptidases as well two bimetallic M17 M28 aminopeptidase families. This...
A series of new derivatives estradiol substituted at position 17alpha by various aryls has been synthesized. This was made possible efficient activation methods for the addition aryllithiums to carbonyl group 17 estrone using tetramethylethylenediamine (TMEDA) or BF3 x OEt2. Their relative binding affinity (RBA) alpha and beta forms estrogen receptor (ER) have measured. All except one compounds synthesized had an RBA value around 10 % which indicates a level tolerance towards bulky...
The synthesis of two new polyhydroxylated indolizidines by stereoselective allylsilane addition to tertiary N-acyliminium ions at a bicyclic ring junction is described. Starting from readily available A (N. Langlois, B. K. Le Nguyen J. Org. Chem. 2004, 69, 7558-7564), two-step procedure leads stereoselectively B bearing quaternary allyl group. Chiral auxiliary removal followed simple silicon protection and N-allylation affords intermediate C, which, upon subjection metathesis,...