A5003627362- Platelet Disorders and Treatments
- Blood properties and coagulation
- Hemophilia Treatment and Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood groups and transfusion
- Chronic Lymphocytic Leukemia Research
- Glycosylation and Glycoproteins Research
- Vascular Malformations and Hemangiomas
- Heparin-Induced Thrombocytopenia and Thrombosis
- Autoimmune Bullous Skin Diseases
- Chronic Myeloid Leukemia Treatments
- Immunodeficiency and Autoimmune Disorders
- Hemostasis and retained surgical items
- Blood disorders and treatments
- Intramuscular injections and effects
- Acute Myeloid Leukemia Research
- Blood Coagulation and Thrombosis Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Inflammatory Bowel Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Skin and Cellular Biology Research
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune and Inflammatory Disorders
- Proteoglycans and glycosaminoglycans research
- Abdominal Trauma and Injuries
Hospital La Paz Institute for Health Research
2018-2025
Hospital Universitario La Paz
2018-2025
BioMarin (United States)
2024
Takeda (United States)
2024
Novartis (Switzerland)
2024
Novo Nordisk (Mexico)
2024
Bayer (United States)
2024
Novo Nordisk (Switzerland)
2024
Takeda (France)
2024
Hospital Universitario Miguel Servet
2024
Abstract The treatment goal for patients with immune thrombocytopaenia (ITP) is to raise platelet counts levels that minimize or stop bleeding. Thrombopoietin receptor agonists (TPO-RAs) have been successfully and extensively employed as second-line therapy ITP. However, TPO-RAs a small but significant increase in the risk of thrombosis. aim this study was elucidate mechanisms involved pro-coagulant effect take them into account when considering their use ITP concomitant diseases/conditions...
Multifactorial mechanisms leading to diminished platelet counts in immune thrombocytopaenia (ITP) might condition the ability of patients with ITP respond treatments. Examining their and features, we aimed detect singular characteristics who do not any treatment. We studied chronic primary had been without treatment, or untreated (UT-ITP), for at least six months; included were responders agonists thrombopoietin receptors (TPO-RA), showed no response first- second-line treatments (NR-ITP),...
Summary Despite the efficacy of splenectomy for chronic immune thrombocytopenia (ITP), its considerable failure rate and possible related complications prove need further research into potential predictors response. The platelet sequestration site determined by 111 In‐labelled autologous scintigraphy has been proposed to predict outcome, but without standardisation in clinical practice. Here, we conducted a single‐centre study analysing cohort splenectomised patients with ITP whom...
Abstract Background Inpatients with Inflammatory Bowel Disease (IBD) are at risk for thromboembolic events, but the flaring outpatients is less understood1. Global Coagulation Assays (GCA) (Thrombin generation assay using Calibrated Automated Thrombogram [CAT] and Rotational Thromboelastometry [ROTEM]) have emerged as aiding tools in assessment of hypercoagulable states2. Methods Cross sectional, case-control study IBD outpatients, both Crohn’s (CD) Ulcerative Colitis (UC). Clinical activity...
X-linked immunodeficiency with magnesium defect, Epstein-Barr virus (EBV) infection and neoplasia (XMEN) disease is caused by hemizygous loss of function (LOF) gene variants in MAGT1. MAGT1 a plasma membrane transporter (Mg2+) that plays relevant role immune responses acts as second messenger intracellular signaling, but also it involved the glycosylation proteins. Here we report two from different families XMEN disease. A de novo variant c.97_98 delinsC affecting one member family three...
Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a genodermatosis characterized by severe cutaneous and mucosal fragility, frequently complicated multifactorial chronic anemia that responds poorly to conventional therapies. This cross-sectional study investigates the factors contributing in RDEB analyzing representative cohort, was stratified disease severity, iron status, examine their hematological parameters, cytokine profile erythropoietin (EPO)-erythroferrone (ERFE)-hepcidin axis....
Summary Thrombocytopenia has been identified as a common complication of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection in the general population. In an attempt to determine impact coronavirus disease 2019 (COVID‐19) patients with immune thrombocytopenia (ITP), retrospective single‐centre study was performed. Thrombocytosis observed chronic ITP after SARS‐CoV‐2 infection, frequently needing treatment adjustment or even discontinuation therapy. Relapses and newly...
We present the first registry of patients with congenital bleeding disorders and COVID-19. The study has been carried out in Community Madrid, which highest number cases Spain. objective is to understand incidence COVID-19, course disease if it occurs psychosocial occupational impact on this population.We included 345 (246 haemophilia, 69 von Willebrand Disease, two rare 28 carriers haemophilia). A telephone survey was used collect data.Forty-two presented symptoms suggestive infection by...
Loss of sialic acid from the carbohydrate side chains platelet glycoproteins can affect clearance, a proposed mechanism involved in etiopathogenesis immune thrombocytopaenia (ITP). We aimed to assess whether changes glycosylation patients with ITP affected counts, function, and apoptosis. This observational, prospective, transversal study included 82 chronic primary 115 healthy controls. measured activation markers assayed caspase activity, analysing samples using flow cytometry. Platelets...
We aimed to identify the key players in prothrombotic profile of patients with systemic lupus erythematosus (SLE) not mediated by antiphospholipid antibodies, as well potential utility global coagulation tests characterize hemostasis these patients. Patients SLE without antibodies and signs thrombosis were included. The kinetics clot formation determined ROTEM®. Platelet activation markers flow cytometry. Thrombin generation associated Neutrophil Extracellular Traps (NETs) microparticles...
Patients with recessive dystrophic epidermolysis bullosa (RDEB) experience numerous complications, which are exacerbated by inflammatory dysregulation and infection. Understanding the immunological mechanisms is crucial for selecting medications that balance inflammation control immunocompetence. In this cross-sectional study, aiming to identify potential immunotherapeutic targets biomarkers, we delved into interrelationship between clinical severity systemic parameters in a representative...
Hemophilia A (HA) patients under emicizumab prophylaxis may require the concomitant use of procoagulant factors for breakthrough bleedings or immune tolerance induction (ITI). The aim this study is to evaluate ex vivo effect plasma-derived FVIII concentrates containing von Willebrand factor (pdFVIII/VWF) in samples from with severe HA without inhibitors on prophylaxis. Samples healthy controls (HC) and were drawn sodium citrate plus corn trypsin inhibitor tubes spiked increasing...
Abstract Background Platelet-related markers associated with a procoagulant state have been described for Immune-mediated Inflammatory Diseases (IMIDs), but broader profiling of these abnormalities in Bowel Disease (IBD) is lacking. Methods Cross-sectional study to describe and compare platelet biomarkers IBD outpatients, both Crohn’s (CD) Ulcerative Colitis (UC), vs healthy controls (HC). Patients over 18 years old diagnosis CD or UC according the European Organization (ECCO) criteria were...
Introduction:The increase in life expectancy among individuals with haemophilia recent years has led to a rise age-related comorbidities.Alongside the emergence of new treatments and their more frequent use various clinical scenarios such as surgeries, invasive diagnostic procedures, on-demand treatment for bleeding episodes, there is need train nursing staff from units other than haematology handling, preparation administration haemostatic treatment.Methods: An educational workshop was...
Abstract Objective The occurrence of unpredictable pain crises are the principal determinant quality life for patients with venous malformations (VM). A definite coagulation phenomenon, characterized by an increase in D‐dimer levels and presence phleboliths within malformation, has been previously reported. By applying Virchow's triad evaluating intralesional samples, our objective is to delineate profile extent endothelial dysfunction malformation. Methods With authorization Ethics...
Background and Objectives: The aim of this study was to determine the impact COVID-19 pandemic on lives patients with immune thrombocytopaenia (ITP) treated at our hospital. Materials Methods: conducted in Community Madrid, which has highest number cases Spain. We included 143 adult ITP (130 chronic ITP, 8 persistent 5 newly diagnosed ITP). a telephone survey collect data created registry. Overall, 24 presented symptoms suggestive COVID-19, confirmed by RT-PCR cases. cumulative incidence...
Abstract Etiopathogenesis of myelodysplastic syndrome (MDS) might cause per se an anomalous haemostasis that can be even more deteriorated by thrombocytopaenia. So, evaluation in patients with MDS rises as a necessity. This work aimed to characterize non-bleeder platelet count similar healthy controls establish differences between the two groups not related Thromboelastometry samples from suggested existence at least antagonistic processes: one them giving hypocoagulable pattern (prolonged...