A5056611142- T-cell and Retrovirus Studies
- Single-cell and spatial transcriptomics
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Axon Guidance and Neuronal Signaling
- Algal biology and biofuel production
- Genomics and Phylogenetic Studies
- Polyamine Metabolism and Applications
- Neuroscience and Neuropharmacology Research
- Biocrusts and Microbial Ecology
- Mitochondrial Function and Pathology
- Microbial Community Ecology and Physiology
Wellcome Sanger Institute
2021-2022
University of Edinburgh
2021
Nankai University
2020
Abstract During activation, T cells undergo extensive gene expression changes that shape the properties of to exert their effector function. Understanding regulation this process could help explain how genetic variants predispose immune diseases. Here, we mapped effects on (expression quantitative trait loci (eQTLs)) using single-cell transcriptomics. We profiled 655,349 CD4 + cells, capturing transcriptional states unstimulated and three time points cell activation in 119 healthy...
Abstract During activation, T cells undergo extensive changes in gene expression which shape the properties of to exert their effector function. Therefore, understanding genetic regulation during cell activation provides essential insights into how variants influence response infections and immune diseases. We generated a single-cell map quantitative trait loci (eQTL) across time-course. profiled 655,349 CD4 + naive memory cells, capturing transcriptional states unstimulated three time...