A5047634769- Cardiovascular Issues in Pregnancy
- Apelin-related biomedical research
- Cardiovascular Function and Risk Factors
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
University of Alberta
2021
Canadian VIGOUR Centre
2019
Sustained, indolent immune injury of the vasculature a heart transplant limits long-term graft and recipient survival. This is mitigated by poorly characterized, maladaptive repair response. Vascular endothelial cells respond to proangiogenic cues in embryo differentiation specialized phenotypes, associated with expression apelin. In adult, role developmental established largely unknown. We found that human minor histocompatibility–mismatched donor mouse allografts alloimmune-mediated...
Myocardial infarction (MI) accounts for a significant proportion of death and morbidity in aged individuals. The risk MI females increases as they enter the peri-menopausal period, generally occurring middle-age. Cytochrome (CYP) 450 metabolizes N-3 N-6 polyunsaturated fatty acids (PUFA) into numerous lipid mediators, oxylipids, which are further metabolised by soluble epoxide hydrolase (sEH), reducing their activity. objective this study was to characterize oxylipid metabolism left...