A5023379792- Axon Guidance and Neuronal Signaling
- Cancer-related gene regulation
- Hippo pathway signaling and YAP/TAZ
- Developmental Biology and Gene Regulation
- Angiogenesis and VEGF in Cancer
University of Southern California
2020-2025
PI3K pathway activation is a common and early event in prostate cancer, from loss of function mutations PTEN, or activating PIK3Ca AKT leading to constitutive activation, induction growth factor-receptors kinase EphB4 its ligand ephrin-B2. We hypothesized that an required for tumor initiation. Secondly, we remains relevant when cancer becomes androgen independent. Genetic mouse model conditional PTEN deletion epithelium induces all mice. tested this against EPHB4 wild type deleted...
The VEGF pathway is critically required for vasculogenesis, the formation of primary vascular network. It also angiogenesis resulting in sprouting and pruning vessels to generate mature arborizing structures. Notch essential arterial-venous specification maturation nascent vessels. We have determined that Tspan18, a member Tetraspanin family, expressed developing but not vasculature zebrafish mouse wound healing. Moreover, reduction at Tspan18 level resulted aberrant patterning, impaired...