A5045319607- Gut microbiota and health
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Child Nutrition and Feeding Issues
- Consumer Market Behavior and Pricing
- Auction Theory and Applications
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- Nutritional Studies and Diet
- Experimental Behavioral Economics Studies
- Vaccine Coverage and Hesitancy
- Misinformation and Its Impacts
- Influenza Virus Research Studies
- Immune Response and Inflammation
- Intergenerational Family Dynamics and Caregiving
- Diabetes and associated disorders
- Eating Disorders and Behaviors
- Metabolomics and Mass Spectrometry Studies
- Respiratory viral infections research
- Psychology of Moral and Emotional Judgment
- Health disparities and outcomes
- Epigenetics and DNA Methylation
- Advanced Glycation End Products research
- COVID-19 and Mental Health
University of Hawaiʻi at Mānoa
2020-2024
Waianae Coast Comprehensive Health Center
2022
University of Hawaii System
2022
In this interventional pilot study, we investigated the effects of a modified ketogenic diet (KD) on children with autism spectrum disorder (ASD). We previously observed improved behavioral symptoms in cohort following KD; trial was registered Clinicaltrials.gov (NCT02477904). This report details alterations microbiota, inflammation markers, and microRNAs seven KD for duration 4 months. Our analysis included blood stool samples, collected before after KD. After months follow up, found that...
Importance Variation in DNA methylation at specific loci estimates biological age, which is associated with morbidity, mortality, and social experiences. Aging known as epigenetic clocks, including the Dunedin Pace of Calculated From Epigenome (DunedinPACE), were trained on data predominately from individuals European ancestry; however, limited research has explored DunedinPACE underrepresented populations experiencing health disparities. Objective To investigate associations neighborhood...
Native Hawaiians and other Pacific Islanders (NHPIs) were disproportionately impacted by COVID-19 remain significantly under-vaccinated against SARS-CoV-2. To understand vaccine hesitancy, we surveyed 1124 adults residing in a region with one of the lowest vaccination rates Hawaii during our testing program. Probit regression analysis revealed that race/ethnicity was not directly associated probability uptake. Instead, higher degree trust official sources information increased 20.68%,...
Abstract While obesity is a risk factor for post-acute sequelae of SARS-CoV-2 infection (PASC, "long-COVID"), the mechanism(s) underlying this phenomenon remains poorly understood. To address gap in knowledge, we performed 6-week longitudinal study to examine immune activity and gut microbiome dysbiosis stage patients recovering from infection. Self-reported symptom frequencies blood samples were collected weekly, with plasma assessed by ELISA Luminex multiple biomarkers cell profiling. DNA...
Vaccine hesitancy remains a significant barrier to achieving herd immunity and preventing the further spread of COVID-19. Understanding contributors vaccine how they change over time may improve COVID-19 mitigation strategies public health policies. To date, no mechanism explains trust in consumption different sources information affect uptake. A total 1594 adults enrolled our testing program completed standardized surveys on demographics, vaccination status, use, reliance, information, from...
Native Hawaiians and Pacific Islanders (NHPIs) suffer from higher prevalence of mortality to type 2 diabetes mellitus (T2DM) than any other major race/ethnic group in Hawaii. Health inequities this indigenous population was further exacerbated by the SARS-CoV-2 pandemic. T2DM progression medical complications COVID-19 are partially regulated gut microbiome. However, there is limited understanding role bacteria context inflammation-related diseases health disparities including obesity. To...
Native Hawaiians and other Pacific Islanders (NHPIs) across the country have experienced significant disparities because of COVID-19 pandemic. The Alliance Against used a community-based participatory approach involving academic community partners to expand sustainable testing capacity mitigate severe consequences among NHPI communities in Hawaii. We describe this one-year study, some results, how data are being inform next steps for communities. Clinical Trials.gov identifier: NCT04766333....
Although vaccines address critical public health needs, inter-individual differences in responses are not always considered their development. Understanding the underlying basis for these is needed to optimize vaccine effectiveness and ultimately improve disease control. In this pilot study, pre- post-antiviral immunological gut microbiota features were characterized examine SARS-CoV-2 mRNA response. Blood stool samples collected before administration of at 2-to-4-week intervals after first...
Abstract While obesity is a risk factor for post-acute sequelae of SARS-CoV-2 infection (PASC, "long-COVID"), the mechanism(s) underlying this phenomenon poorly understood. To address gap in knowledge, we performed 6-week longitudinal study to examine immune activity and gut microbiome dysbiosis stage patients recovering from infection. Self-reported symptom frequencies blood samples were collected weekly, with plasma assessed by ELISA Luminex multiple biomarkers cell profiling. DNA stool at...
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental affecting social interaction and communication, associated with increased levels of inflammation mitochondrial dysfunction. The ketogenic diet has neuroprotective affects decreases the severity related conditions. A cohort 7 children aged to 19 diagnosed ASD have improved behavioral symptoms following diet. This study aims identify changes gut microbiome inflammatory markers that are prognosis. Stool plasma samples were...
Abstract Determining vaccine efficacy in individuals is a concern when managing the spread of virus. In this study pre-vaccination levels panel inflammation factors were measured order to predict SARS-CoV-2 mRNA vaccines by measuring neutralization percentages, antibody concentrations, and over course ten weeks after initial dose vaccine. Blood stool samples collected at time point before administration (pre-vaccination) 2-week intervals first (post-vaccination). A cohort 12 adults (n=12)...
Abstract Native Hawaiians and Pacific Islanders (NHPIs) suffer higher rates of type 2 diabetes mellitus (T2DM) prevalence mortality compared to other racial-ethnic groups in Hawaii. Gut microbiome is recognized as a partial determinant T2DM progression, the role its associated metabolome not well understood context immunometabolic health disparity. We employed community-based research strategies among Oahu, Hawaii residents form cohort enriched with NHPIs (N=98). profiling was achieved via...
Abstract Postacute sequelae of SARS-CoV-2 infection (PASC) is the next public health concern pervasive COVID-19 pandemic. Molecular pathophysiology PASC undetermined, therefore this study evaluated pathways implicated in humoral responses associated with symptom resolution to identify predictive biomarkers PASC. Individuals recovered from acute were recruited into a 6-week study. Initial questionnaires and proof previous collected prior enrollment. Body mass indices calculated participant...