A5066254364- Invertebrate Immune Response Mechanisms
- Insect symbiosis and bacterial influences
- Neurobiology and Insect Physiology Research
- CRISPR and Genetic Engineering
Jackson Laboratory
2024
Indian Institute of Science Education and Research Mohali
2021
truncation variants (TTNtvs) are the most common genetic lesion identified in individuals with dilated cardiomyopathy, a disease high morbidity and mortality rates. TTNtvs reduce normal TTN (titin) protein levels, produce truncated proteins, impair sarcomere content function. Therapeutics targeting have been elusive because of immense size TTN, rarity specific TTNtvs, incomplete knowledge TTNtv pathogenicity.
Immune challenges demand the gearing up of basal hematopoiesis to combat infection. Little is known about how during development, this switch achieved take care insult. Here, we show that hematopoietic niche larval lymph gland Drosophila senses immune challenge and reacts it quickly through nuclear factor-κB (NF-κB), Relish, a component deficiency (Imd) pathway. During Relish triggered by ecdysone signaling in maintain blood progenitors. Loss causes an alteration cytoskeletal architecture...
Drosophila larval hematopoiesis occurs in a specialized multi-lobed organ called the lymph gland. Extensive characterization of has provided mechanistic insights into events related to developmental hematopoiesis. Spanning from thoracic abdominal segment larvae, this comprises pair primary, secondary, and tertiary lobes. Much our understanding arises studies on primary lobe, while secondary lobes have remained mostly unexplored. Previous inferred that these are composed progenitors...
Abstract Immune challenges demand the gearing up of basal hematopoiesis to combat infection. Little is known about how during development, this switch achieved take care insult. Here, we show that hematopoietic niche larval lymph gland Drosophila senses immune challenge and reacts it quickly through nuclear factor-κB (NF-κB), Relish, a component deficiency (Imd) pathway. During Relish triggered by ecdysone signaling in maintain blood progenitors. Loss causes an alteration cytoskeletal...