Lixuen Siow

ORCID: 0000-0002-8067-8772
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Bone Tissue Engineering Materials
  • Dental Trauma and Treatments
  • Palliative Care and End-of-Life Issues
  • Dental Health and Care Utilization
  • Grief, Bereavement, and Mental Health
  • Oral microbiology and periodontitis research
  • MicroRNA in disease regulation
  • Orthodontics and Dentofacial Orthopedics
  • dental development and anomalies
  • Dental Implant Techniques and Outcomes
  • Oral and Maxillofacial Pathology
  • 3D Printing in Biomedical Research
  • Orthopedic Infections and Treatments
  • DNA and Nucleic Acid Chemistry
  • Geriatric Care and Nursing Homes
  • RNA Interference and Gene Delivery
  • Dental Radiography and Imaging
  • Bone Metabolism and Diseases
  • Advanced biosensing and bioanalysis techniques
  • Cleft Lip and Palate Research
  • Antimicrobial Peptides and Activities
  • Extracellular vesicles in disease
  • Patient Dignity and Privacy
  • Additive Manufacturing and 3D Printing Technologies
  • Dental Erosion and Treatment

Zhejiang University
2022-2025

Stomatology Hospital
2022-2025

Zhejiang University Medical College Affiliated Stomatological Hospital
2023

Tongji University
2023

Abstract Reconstruction of irregular oral-maxillofacial bone defects with an inflammatory microenvironment remains a challenge, as chronic local inflammation can largely impair healing. Here, we used magnesium silicate nanospheres (MSNs) to load microRNA-146a-5p (miR-146a) fabricate nanobiomaterial, MSN+miR-146a, which showed synergistic promoting effects on the osteogenic differentiation human dental pulp stem cells (hDPSCs). In addition, miR-146a exhibited anti-inflammatory effect mouse...

10.1038/s41413-023-00299-0 article EN cc-by Bone Research 2024-01-15

Osteomyelitis, caused by purulent bacteria invading bone tissue, often occurs in long bones and seriously affects the physical mental health working ability of patients; it can even endanger life. However, due to cavity structure, osteomyelitis tends occur inside thus lacks an effective treatment; anti-inflammatory treatment repair defects are necessary. Here, we developed injectable hydrogel microspheres loaded with naringin marrow mesenchymal stem cells, which have osteogenic properties....

10.1088/1758-5090/aceaaf article EN Biofabrication 2023-07-26

Background China ranks 53 rd out of 81 countries in the Quality Death Index for 2021. Although hospice care demand is increasing, progress remains slow. It great significance to explore acceptances and associated influencing factors care. Methods A cross-sectional survey by quota sampling was conducted from July 10 th September 15 , We collected demographic data acceptance. stepwise linear regression analysis used. Results This contained 11,031 valid questionnaire results investigate found...

10.3389/fpubh.2022.985218 article EN cc-by Frontiers in Public Health 2022-09-23

Abstract Background In the 21st century, dental caries remains a global burden, particularly severely affecting growth and quality of life 12-year-old children. Fortunately, pit fissure sealing (PFS) procedures can effectively prevent molars from caries. Hence, this study focused on relationship between PFS oral epidemiological factors in Methods A cross-sectional survey was conducted children 11 cities Zhejiang Province. Their conditions were collected through questionnaires, as well basic...

10.1186/s12887-024-04767-2 article EN cc-by BMC Pediatrics 2024-08-02

(1) Objectives: This study evaluated the clinical outcomes of dental implants placed in previously failed sites and discussed risk factors that mattered reimplantation. (2) Methods: All cases by one specific implantologist during his first five years practice were screened, with a focus on those who received The assessed, including implant survival, peri-implant health, patients’ satisfaction. (3) Results: 28 patients (31 implants) recorded as failures from 847 (1269 implants), 2.4% overall...

10.3390/ijerph192315939 article EN International Journal of Environmental Research and Public Health 2022-11-29

Abstract Background The World Health Organization (WHO) recommends the age of 12 years as target for global caries detection. Insufficient mineralization, pits, and grooves on tooth surface can lead to accumulation food residues, increasing risk in children's newly erupted teeth, within 2–4 years. Therefore, it is important emphasize health teeth adolescents take measures prevent carie. Approximately 90% children’s permanent occur pits fissures posterior teeth. Pit fissure closure...

10.21203/rs.3.rs-2435837/v1 preprint EN cc-by Research Square (Research Square) 2023-01-09

Abstract The reconstruction of irregular oral-maxillofacial bone defects with an inflammatory microenvironment remains a clinical challenge as chronic local inflammation can largely impair healing. Here, we used magnesium silicate nanospheres (MSN) to load nucleic acid drug - microRNA146a-5p (miR146a), fabricating nanobiomaterial complex MSN-miR146a high oligo transfection efficiency. This showed potent promoting effect on osteogenic differentiation human dental pulp stem cells upregulated...

10.21203/rs.3.rs-2830326/v1 preprint EN cc-by Research Square (Research Square) 2023-05-08

Abstract Objectives This retrospective study was intended to evaluate the clinical accuracy of partially guided template in guiding implant placement edentulous patients. Methods A total 120 implants were placed 24 patients with at least one completely arch a system. Based on CBCT data, repeatable method used measure linear and angular deviations 3D level Mimics medical software. The influence supporting tissue region assessed, followed by evaluation direction biologically vital areas....

10.1111/clr.14191 article EN Clinical Oral Implants Research 2023-10-10
Coming Soon ...