Current medical imaging technologies allow visualization of tissue anatomy in the human body at resolutions ranging from 100 micrometers to 1 millimeter. These are generally not sensitive enough detect early-stage abnormalities associated with diseases such as cancer and atherosclerosis, which require micrometer-scale resolution. Here, optical coherence tomography was adapted high-speed a living animal catheter-endoscope millimeter diameter. This method, referred “optical biopsy,” used...

Background Optical coherence tomography (OCT) is a recently developed medical diagnostic technology that uses back-reflected infrared light to perform in situ micron scale tomographic imaging. In this work, we investigate the ability of OCT imaging internal microstructure vitro atherosclerotic plaques. Methods and Results Aorta relevant nonvascular tissue were obtained at autopsy. Two-dimensional cross-sectional exposed surface arterial segments was performed with OCT. A 1300-nm wavelength,...

We describe two new techniques, based on optical coherence tomography (OCT), for determining the refractive index of highly scattering human tissue. obtained indices in vitro tissue, using OCT to measure physical and path lengths sample. measurements vivo track focal length shift that results from translating focus along optic axis within The skin, adipose, muscle were measured compared with previously published estimates.

We describe a new optical coherence tomography catheter–endoscope for micrometer-scale, cross-sectional imaging in internal organ systems. The uses single-mode fiber optics with novel transverse scanning design. distal end of the gradient-index lens microprism to emit and collect single spatial-mode beam specific focusing characteristics. is scanned circumferential pattern can image cross sections through structure into which it inserted. A device diameter as small 1.1 mm has been achieved,...

A Kerr-lens mode-locked Ti:Al(2)O(3) oscillator, optimized for minimal coherence length, is demonstrated as a high-power source high-resolution optical tomographic imaging. Dispersion compensation and heterodyne noise rejection are to yield in situ images of biological tissues with 3.7-mum resolution 93-dB dynamic range.

<h3>BACKGROUND</h3> Optical coherence tomography (OCT) is a new method of catheter based micron scale imaging. OCT analogous to ultrasound, measuring the intensity backreflected infrared light rather than sound waves. <h3>OBJECTIVE</h3> To demonstrate ability perform high resolution imaging arterial tissue in vivo. <h3>METHODS</h3> abdominal aorta New Zealand white rabbits was performed using 2.9 F catheter. Using an ultrashort pulse laser as source for imaging, axial 10 μm achieved....

Background and Study Aims: Endoscopic optical coherence tomography (OCT) is an emerging medical technology capable of generating high-resolution cross-sectional imaging tissue microstructure in situ real time. We assess the use feasibility OCT for real-time screening diagnosis Barrett's esophagus, also review state-of-the-art endoscopic imaging.

BACKGROUND: OCT can image plaque microstructure at a level of resolution not previously demonstrated with other imaging techniques because it uses infrared light rather than acoustic waves. OBJECTIVES: To compare optical coherence tomography (OCT) and intravascular ultrasound (IVUS) in vitro atherosclerotic plaques. METHODS: Segments abdominal aorta were obtained immediately before postmortem examination. Images 20 sites from five patients acquired (operating an wavelength 1300 nm which was...

The uptake and mobilization of (15S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid (15-HETE), a major product arachidonic metabolism, was examined with human neutrophils (polymorphonuclear leukocytes; PMNs). Upon exposure to labeled 15-HETE, PMNs rapidly (15 sec 20 min) incorporated approximately 20% the label into phosphatidylinositol, while less than 4% associated other phospholipid classes neutral lipids. This pattern distinct from that either arachidonate or...

Optical coherence tomography (OCT) is a method of high-resolution imaging originally developed for the transparent tissue eye. Recently, technology has been advanced toward difficult challenge in nontransparent tissue. In paper, three topics are addressed. First, principles behind OCT discussed. Second, difficulties associated with outlined. Finally, feasibility medical Specifically, demonstrates its greatest potential situations where conventional biopsy either dangerous or ineffective.

Studies investigating normal and abnormal cardiac development are frequently limited by an inability to assess cardiovascular function within the intact organism. In this work, optical coherence tomography (OCT), a new method of micron-scale, noninvasive imaging based on measurement backscattered infrared light, was introduced for high resolution assessment structure in developing Xenopus laevis system. Microstructural details, such as ventricular size wall positions, were delineated with...

Optical Coherence Tomography (OCT) is a recently developed non-invasive technique for obtaining high resolution, cross-sectional images of human tissue. This work investigated the capability OCT to differentiate architectural morphology urologic tissue with long term aim using as an adjunct endoscopic imaging and improve efficiency interventional procedures such transurethral prostatectomy (TURP). Urologic tissues were taken postmortem, dissected, imaged OCT. Microstructure was delineated in...

We discuss the design and implementation of forward-imaging instruments for optical coherence tomography (OCT), which require delivery, scanning, collection single-spatial-mode radiation. A hand-held surgical probe use in open surgery can provide cross-sectional images subsurface tissue before incisions are made. rigid laparoscope minimally invasive OCT imaging provides a simultaneous en face view area being imaged. is demonstrated on vitro human specimens.

Background —Most myocardial infarctions are caused by the rupture of small rather than large plaques in arteries heart that beyond detection limit current technologies. Methods and Results —Recently, optical coherence tomography (OCT) has demonstrated considerable potential as a method for high-resolution assessment vulnerable plaque. However, intravascular OCT imaging is complicated need to remove blood from field because results substantial signal attenuation. This work examines index...