A5048211857- Clostridium difficile and Clostridium perfringens research
- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- ATP Synthase and ATPases Research
- Cellular transport and secretion
- Enterobacteriaceae and Cronobacter Research
- Wnt/β-catenin signaling in development and cancer
- Cancer, Hypoxia, and Metabolism
- Viral gastroenteritis research and epidemiology
- Mycobacterium research and diagnosis
- Escherichia coli research studies
- Wound Healing and Treatments
- Microbial Metabolism and Applications
- Pharmacological Effects of Natural Compounds
- Ion Transport and Channel Regulation
Fujieda Municipal General Hospital
2020
Tokushima University
2012-2013
Institute of Public Health
1997
We previously showed that R ab13 and its effector protein, junctional ab13‐binding protein ( JRAB )/molecules interacting with C as L ‐like 2 MICAL ‐L2), regulate development by modulating cell adhesion molecule transport actin cytoskeletal reorganization in epithelial cells. Here, we investigated how regulates of the cytoskeleton NIH 3T3 fibroblasts, an attempt to obtain novel insights into mechanism action. To this end, expressed mutant proteins adopt a constitutively open or closed state...
Abstract Pseudohypoaldosteronism type II (PHA II) is inherited in an autosomal dominant manner and characterized by hypertension, hyperkalemia, hyperchloremic metabolic acidosis. The enhancement of with‐no‐lysine kinase (WNK) functions correlated to the pathogenesis condition. Cullin 3 (CUL3) forms E3 ubiquitin ligase complex, it can ubiquitinate WNK. Most CUL3 gene mutations are distributed sites, such as intron 8 splice acceptor, 9 donor, putative branch which involved splicing exon 9....
PCR法を基礎とした食中毒原性ウェルシュ菌の検出および疫学的解析法について有効性を検討した.今回検討したPCR法やNested PCR法は, 菌株において103から100CFUの感度を示し, 食品や土壌などの環境材料に応用した結果から, ウェルシュ菌cpe遺伝子の検出を迅速, 簡易かつ高感度に行うことが可能であると考えられた.一方, 分離菌株の疫学解析法としてPCR-RFLP法およびRAPD法を検討した結果, PCRRFLPは集団例菌株の識別手法としては有効性は乏しいと考えられたが, RAPD法はその有効性が示唆された.今後これらを用途によって適宜組み合わせて利用することにより, 食中毒発生時の病原検索やウェルシュ菌の分子疫学あるいは細菌学的な調査研究に有効な解析法となると考えられた.