A5025734307- Ear and Head Tumors
- Nonmelanoma Skin Cancer Studies
- Head and Neck Cancer Studies
- Cancer and Skin Lesions
- Crustacean biology and ecology
- Salivary Gland Tumors Diagnosis and Treatment
- Fish Biology and Ecology Studies
- Cancer Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Marine and fisheries research
- Polyomavirus and related diseases
- Head and Neck Surgical Oncology
- Fish biology, ecology, and behavior
- Cardiac, Anesthesia and Surgical Outcomes
- Reconstructive Facial Surgery Techniques
- Assisted Reproductive Technology and Twin Pregnancy
- Marine Biology and Ecology Research
- Viral-associated cancers and disorders
- Antenna Design and Analysis
- Reproductive Health and Technologies
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- Advances in Oncology and Radiotherapy
- Lymphoma Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
The University of Sydney
2008-2022
Westmead Hospital
2011-2022
Cancer Australia
2016
Royal Prince Alfred Hospital
2016
Evelina London Children's Healthcare
2016
Kentuckiana Pulmonary Associates
2012-2015
Concord Repatriation General Hospital
2005-2007
Blacktown & Mount Druitt Hospital
2007
Medical Research Council
2005
Dartmouth–Hitchcock Medical Center
1981-2003
Patients with cutaneous squamous cell carcinoma (SCC) may develop metastatic SCC to nodes in the head and neck. Recent data support best outcome addition of adjuvant radiotherapy. This study aims present further supportive evidence.Retrospective chart review.Patients were identified neck treated surgery or Relapse analyzed using Cox regression analysis. Disease-free survival overall rates calculated Kaplan-Meier curves.Between 1980 2000, 167 patients curative intent at Westmead Hospital,...
Anticardiolipin antibodies (aCL) purified from patients with autoimmune disease have recently been shown to interact a phospholipid-binding plasma protein, β 2 -glycoprotein I (β -GPI). The aim of this study was determine whether aCL infection also -GPI. 23 malaria, infectious mononucleosis, tuberculosis, hepatitis A or syphilis did not require the presence -GPI bind cardiolipin (CL). In contrast, were 11 out 12 that bound CL only in Thrombotic complications appear be associated occurring...
Mutations in the p53 and retinoblastoma (pRb) pathways associated with use of tobacco alcohol are common squamous cell carcinoma (SCC) head neck. Cell cycle proteins also affected by human papillomavirus (HPV), which may have an aetiological role cancers at particular sites, most notably tonsil. Attempts to identify prognostic molecular markers neck met conflicting results, but few studies been undertaken tumours known HPV status a single anatomic site. In our study 86 tonsil were analysed...
Most patients with cutaneous squamous cell carcinoma (cSCC) of the head and neck (HN) are at low-risk (<5%) developing metastatic SCC to regional lymph nodes. However, unfavorable clinicopathologic factors often under appreciated by clinicians but remain higher risk for node disease dying.Patients were identified who had cSCC nodes (parotid cervical) HN treated within context a multidisciplinary cancer service between 1980 2005 Westmead Hospital (Sydney, Australia). Relevant patient details...
Abstract Background. Among patients with cutaneous squamous cell carcinoma (SCC) of the head and neck, recent studies have shown that those involvement parotid gland also a high incidence neck node involvement. Treatment by either surgery or radiotherapy is therefore recommended among SCC, even if clinical examination negative. The aim this study was first to analyze patterns metastatic spread in cervical lymph nodes then correlate pattern involved primary site order guide appropriate extent...
Abstract BACKGROUND Cutaneous squamous cell carcinoma (SCC) of the head and neck is a common cancer that has potential to metastasize lymph nodes in parotid gland neck. Previous studies have highlighted limitations with current TNM staging system for metastatic skin carcinoma. The aim this study was test new may provide better discrimination between patient groups. METHODS A retrospective multicenter conducted on 322 patients from three Australian North American institutions. All had...
Merkel cell carcinoma is an aggressive primary cutaneous neuroendocrine carcinoma. Patients remain at high risk of locoregional and distant relapse despite treatment. Most studies support the incorporation adjuvant radiotherapy in reducing relapse.Between 1980 2002, 86 patients diagnosed with were treated curative intent Westmead Hospital, Sydney. Multivariate analysis was performed using Cox regression analysis. Disease-free survival overall calculated Kaplan-Meier curves.Median age...
Abstract Objective : The aim of this study is to report on the experience treating cutaneous squamous cell carcinoma (SCC) metastatic cervical (nonparotid) lymph nodes at Head and Neck Unit, Westmead Hospital, Sydney, Australia. Study Design Retrospective chart review. Methods Patients diagnosed with previously untreated SCC (levels I‐V) treated radiotherapy, surgery, or surgery adjuvant radiotherapy were identified. Relapse outcome was analyzed using Cox regression analysis. Results Between...
: The authors propose a prognostic score model using prospective study of patients with regional metastatic cutaneous squamous cell carcinoma the head and neck.: Two-hundred fifty were analyzed competing risks to identify risk factors for survival. A was obtained significant coefficients from regression model, cutoff points determined that separated into 3 groups (low risk, moderate high risk).: At median follow-up 54 months (range, 1.3-212 months) 70 250 (28%) developed recurrent disease:...
The purpose of this study was to compare the outcome surgery against plus radiotherapy in patients with metastatic cutaneous head and neck squamous cell carcinoma (HNSCC) cervical nodes.We conducted a 28-year retrospective analysis 122 whom were treated for HNSCC involving nodes (levels I-V).After alone, 11 (55%) developed recurrence compared 23 (23%) after radiotherapy. On multivariate analysis, following variables significantly associated disease-free survival (DFS): immunosuppression (p =...
BACKGROUND Head and neck cancer (HNC) encompasses a diverse group of tumors, thus providing appropriate tailored information to patients before, during, after treatment is challenge. The objective the current study was characterize experience unmet needs with HNC regard support provision. METHODS A 28‐question, cross‐sectional survey completed by treated for at 1 4 institutions in New South Wales, Australia (Chris O'Brien Lifehouse Liverpool, Westmead, Wollongong hospitals). It consisted...
To test a new clinical staging system in patients with metastatic cutaneous squamous cell carcinoma involving the parotid gland or lymph nodes of neck.Retrospective analysis clinicopathological data from minimum 2 years' follow-up.Multidisciplinary head and neck unit tertiary referral center.Between 1987 1999, 126 (104 men 22 women; median age, 69 years) were treated for and/or neck.Locoregional recurrence disease-specific survival.Of patients, disease involved 81 whom 14 also had disease,...
Abstract Background Pindborg tumors (calcifying epithelial odontogenic tumors) are uncommon neoplasms of origin most often located in the posterior mandible. First described detail 1955 by Pindborg, these considered benign but can be locally aggressive nature, with recurrence rates 10% to 15% reported. The malignant form this tumor is exceedingly rare. Methods We describe case a 64‐year‐old woman initially treated for painful infected left mandibular third molar. patient underwent extraction...
Australians have the highest rate of skin cancer in world. Merkel cell carcinoma (MCC) is most aggressive reported, with a high propensity for relapse. The purpose this study was to report patterns recurrence after initial treatment, outcomes, and any predictors survival.We identified 37 patients who were diagnosed MCC head neck between 1980 2002. In retrospective analysis, multivariate analysis performed by use Cox regression analysis. Disease-free survival (DFS) overall (OS) calculated...
The treatment of squamous cell carcinoma the lip with surgery is usually curative but incomplete/inadequate excision may be associated recurrence and poor outcome. There no consensus in literature on definition an adequate margin.Patients treated for at Westmead Hospital, Sydney, between 1980 2000 were eligible inclusion. Polytomous logistic regression analysis was undertaken to assess predictors recurrence. Recurrence-free overall survival calculated using Kaplan-Meier curves.A total 130...
Background: There is an increasing risk of cervical lymph node metastases as tumour thickness increases in patients with anterior tongue squamous cell carcinoma (SCC). The role elective neck treatment early cancer unclear. Methods: Patients diagnosed and treated glossectomy ± dissection were identified. aim was to document the incidence pathological outcome thickness. Cox proportional hazards model used identify prognostic factors. Survival curves calculated using Kaplan−Meier method....