A5100721707- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Virus-based gene therapy research
- Electrospun Nanofibers in Biomedical Applications
- Neurology and Historical Studies
- Neuropeptides and Animal Physiology
- Venous Thromboembolism Diagnosis and Management
- Acute Myocardial Infarction Research
- Cardiovascular Syncope and Autonomic Disorders
- Gestational Diabetes Research and Management
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Healthcare and Environmental Waste Management
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- RNA Interference and Gene Delivery
- Cardiac Structural Anomalies and Repair
- Mesenchymal stem cell research
- Congenital heart defects research
- Traditional Chinese Medicine Analysis
Soochow University
2014-2023
First Affiliated Hospital of Soochow University
2014-2023
Nanjing Medical University
2014
Periostin was proved to play an important role in extra-cellular matrix remodeling after acute myocardial infarction (AMI). Myocardial periostin markedly up-regulated AMI and participated the maladaptive process of cardiac remodeling. However, few researches focused on circulating its significance. This study aims investigate association serum level with function short-term prognosis patients.We totally recruited 50 patients diagnosed as ST-elevation infarction. Blood samples were taken...
Stem cell antigen-1-positive (Sca-1+) cardiac stem cells (CSCs) therapy for myocardial regeneration following acute infarction (AMI) is limited by insufficient viability and a high rate of apoptosis, due to the poor regional microenvironment. Resveratrol, which compound extracted from red wine, has been reported protect tissue post‑AMI increasing expression angiogenic chemotactic factors. The present study aimed investigate effects resveratrol on Sca‑1+ CSCs, optimize CSCs post‑AMI. C57/BL6...
Background Some clinical studies have demonstrated that the proton pump inhibitor (PPI) could decrease clopidogrel platelet response and increase major adverse cardiovascular events (MACE) in white or black subjects. However, remains to be determined Chinese patients. In this study, we sought determine whether there an increased risk for developing MACE after concomitant use of dual antiplatelet therapy (DAT) a PPI patients treated with percutaneous coronary intervention (PCI) stenting....
Cardiac stem cells (CSCs) are important for improving cardiac function following myocardial infarction, with CSC migration to infarcted or ischemic myocardium regeneration. Strategies improve cell may the efficiency of Basic fibroblast growth factor (bFGF) is an essential molecule in migration, but endogenous bFGF level too low be effective. The effect exogenously delivered on was observed vitro and vivo present study. index response various concentrations demonstrated vitro. In addition, a...
The aim of the present study was to determine effects short-term application pantoprazole on co-treatment acute ST-segment elevation myocardial infarction (STEMI) with aspirin and clopidogrel. A total 207 patients showing primary symptoms STEMI, who received successful emergent percutaneous coronary intervention treatment during hospitalization were randomly divided into two groups. In test group proton pump inhibitors (PPIs), treated a combination clopidogrel pantoprazole, while those in...
To investigate the main causes, risk factors, and prognosis of patients hospitalized with syncope.The admitted due to syncope were included. We analyzed etiology, an average follow-up 15.3 months.High-risk factors for cardiogenic included age ≥60, male, hypertension, palpitation, troponin T-positive, abnormal ECG, CHD history, syncope-related trauma. Mortality rate was 4.6%, recurrence 10.5%, rehospitalization 8.5%. Univariate analysis showed that related ≥60 years old, positive T,...
Abstract: There is increasing concern about heart failure after myocardial infarction and the current clinical treatment measures for ventricular remodeling. Herein, we present results of differential gene analysis, pathway enrichment characteristic screening. Our study identifies 4 core genes ( KLRC2 , SNORD105 SNORD45B RNU5A-1 ) associated with post-acute (AMI) failure. The authors discuss significance identified genes, their potential implications in immune dysfunction failure, relevance...