To determine the time of acceleration in white matter hyperintensity (WMH) burden, a common indicator cerebrovascular pathology, relation to conversion mild cognitive impairment (MCI) elderly.A total 181 cognitively intact elderly volunteers from longitudinal, prospective, Oregon Brain Aging Study underwent yearly evaluations, including brain MRI, and testing. MRIs were analyzed for imaging markers neurodegeneration: WMH ventricular CSF (vCSF) volumes. The before MCI, when changes vCSF...

White matter hyperintensities (WMHs) are common with age, grow over time, and associated cognitive motor impairments. Mechanisms underlying WMH growth unclear. We aimed to determine the presence extent of decreased normal appearing white (NAWM) cerebral blood flow (CBF) surrounding WMHs identify 'WM at risk', or CBF penumbra. further validate cross-sectional finding by determining whether baseline penumbra predicts development new follow-up. Sixty-one cognitively intact elderly subjects...

<h3>Objective</h3> We aimed to describe and compare baseline cerebral blood flow (CBF) microstructural characteristics of normal-appearing white matter (NAWM) within the vulnerable periventricular hyperintensity (PVWMH) penumbra region in predicting (WMH) growth over time. <h3>Methods</h3> Fifty-two patients, aged 82.8 years, underwent serial brain MRI, including pulsed arterial spin labeling diffusion tensor imaging (DTI). New WMH persistent NAWM voxels relation at follow-up were...

Normal-appearing white matter (NAWM) surrounding WMHs is associated with decreased structural integrity and perfusion, increased risk of WMH growth, referred to as the penumbra. Studies comparing cerebral blood flow (CBF) penumbras within same individuals are lacking, however, would facilitate our understanding mechanisms resulting in WM damage. This study aimed compare both CBF non-demented aging. Eighty-two elderly volunteers underwent 3T-MRI including fluid attenuated inversion recovery...

Purpose To describe a fully automated segmentation method that yields object-based morphologic estimates of enlarged perivascular spaces (ePVSs) in clinical-field-strength (3.0-T) magnetic resonance (MR) imaging data. Materials and Methods In this HIPAA-compliant study, MR data were obtained with 3.0-T imager research participants without dementia (mean age, 85.3 years; range, 70.4–101.2 years) who had given written informed consent. This is built on (a) relative normalized white matter,...

Objective Periventricular white matter hyperintensities (pvWMHs) are commonly observed on MRI in older individuals and associated with cognitive motor decline. The etiology of pvWMH remains unknown. Venous collagenosis has been implicated, which may also interfere perivascular fluid flow leading to dilation spaces (PVS). Here, we examine relationships between vivo volume ex morphological quantification the PVS veins arteries. Methods Brain tissue from 25 Oregon Alzheimer's Disease Research...

Despite having a meaningful impact on quality of life, emotional well-being is often understudied in older adults favor cognitive performance, particularly when examining association with neurobiological function. Socially-isolated have poorer health than their non-isolated peers and are at increased risk dementia. Characterizing correlates characteristics this population may help elucidate pathways which link social isolation dementia risk. In sample 50 socially-isolated aged 75+ years...

Background:Cerebrovascular disease is a common cause of dementia in older adults, and potentially preventable with early intervention. Oxylipins are produced from the oxidation long-chain polyunsaturated fatty acids (PUFA) possessing potent vascular effects. generated cytochro me P450 pathway enzymatically converted to diols by soluble epoxide hydrolase (sEH); sEH products have been associated small vessel ischemic disease. Little known about oxylipins' impact on markers risk. Objective:An...

Background: Computer use is becoming a common activity in the daily life of older individuals and declines over time those with mild cognitive impairment (MCI).The relationship between computer (DCU) imaging markers neurodegeneration unknown.Objective: The objective this study was to examine average DCU volumetric on brain MRI.Methods: Cognitively intact volunteers enrolled Intelligent Systems for Assessing Aging Change underwent MRI.Total in-home per day calculated using mouse movement...

Marilyn Huckansabcd*, Adriana Seelyeabf, Jonathan Woodhouseabg, Tiffany Parcelabh, Lisa Mullabh, Daniel Schwartzbcd, Alex Mitchellbcd, David Lahnabcd, Amy Johnsonab, Jennifer Loftisabcd, Steven Paul Woodsi, Suzanne H. Mitchellde & William Hoffmanbcd a Northwest Hepatitis C Resource Center , Portland VA Medical Portland, OR, USA b Research Division c Behavioral Health Clinical Neurosciences d Department of Psychiatry Oregon and Science University e f Washington State Pullman, WA, g George Fox...

Importance Older adults with lower intake and tissue levels of long-chain ω-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA; 20:5) docosahexaenoic (DHA; 22:6) have more brain white matter lesions (WMLs), an association suggesting that small-vessel ischemic disease, a major contributor to the development dementia, including Alzheimer may be preventable through treatment. Objective To determine whether treatment reduces WML accumulation in older without dementia harboring WMLs...

Background: Cortical gray matter (GM) and white (WM) deterioration are signals of neurodegeneration increased dementia risk; however, their specific etiologies in dementia-free aging is unclear.Objective: The objective this study was to examine potentially modifiable risk factors GM WM degeneration a well-characterized cohort elderly.Methods: 96 Okinawan elderly participants (age 83.6) from the Keys Optimal Cognitive Aging Project (KOCOA) underwent MRI cognitive evaluation.Serum markers...

Vascular risk factors for age-related cognitive decline are significant, and their management may ultimately prove the most successful strategy reducing sustaining health. This randomized, double-blinded, placebo-controlled trial with parallel group allocation to either marine n-3 polyunsaturated fatty acids (n-3 PUFA) or soybean oil placebo assesses effects on total volume of accumulation in cerebral white matter hyperintensities (WMH), a potentially modifiable neurovascular component...

Postmortem (PM) magnetic resonance imaging (MRI) can serve as a bridge between in vivo and histology by connecting MRI observed macrostructural findings to histological staining microstructural changes. Data were acquired from 20 formalin-fixed brains including T2, T1, PD, T2*-weighted images of left hemispheres 6-mm-thick coronal slices. Tissue slices bisected, aligned MR used guide sampling. Markers myelin oligodendroglia alterations semiquantitatively rated compared within white matter...

Age-related magnetic resonance imaging (MRI) T2 white matter hyperintensities (WMHs) are common and associated with neurological decline. We investigated the histopathological underpinnings of MRI WMH surrounding normal appearing (NAWM), a focus on astroglial phenotypes.

A 63-year-old man with 6 months of mild left hand rest tremor and bradykinesia subtle wrist cogwheel rigidity was diagnosed idiopathic Parkinson disease (PD). The most profound neuronal degeneration in PD occurs nigrosome 1, a lens-shaped substructure the substantia nigra containing approximately 22,000 cell bodies each hemi-midbrain, measuring × 1 mm.1,2 7T MRI at caudal level red nucleus (figure, A) shows signal present absent right, consistent clinically affected side. healthy normal...

Abstract Background MR‐visible perivascular space (PVS) burden is associated with clinical and MRI features of cerebrovascular disease. Its utility as an in vivo biomarker post‐mortem pathology uncertain. Method Eighteen older adults (age at death 98.0, sd 5.5; 83% female) autopsy consent were followed longitudinally the Oregon Alzheimer’s Disease Research Center cognitive assessments until death. In white matter (WM) PVS volumes derived using automated segmentation algorithm based on T1...

Abstract Background The n‐3 PUFA may modulate risk for age‐related cognitive impairment through vascular mechanisms. MRI derived cerebral white matter hyperintensities (WMH) presumptively reflect small vessel disease and their accumulation increases decline dementia. Blood are consistently associated with reduced WMH stroke. primary aim here was to evaluate supplementation on over 3 years in an older population evidence of absence supplementation. Methods study a double‐blind,...

Abstract Background Previous studies investigating potential beneficial effects of Omega‐3 Polyunsaturated Fatty Acids (PUFA) on vascular health have shown inconsistent results. Oxylipins, produced from the oxidation PUFAs, potent to be relevant human disease. We previously reported cytochrome P450‐derived PUFA Docosahexaenoic acid (DHA) oxylipin 16,17‐EpDPE associated with less cerebral white matter hyperintensities (WMH), while a ratio its soluble epoxide hydrolase (sEH) products,...