A5040500129- Chemical Synthesis and Analysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Marine Sponges and Natural Products
- Carbohydrate Chemistry and Synthesis
- Synthetic Organic Chemistry Methods
- Crystallography and molecular interactions
- Asymmetric Synthesis and Catalysis
- Molecular Sensors and Ion Detection
- Click Chemistry and Applications
- Microbial Natural Products and Biosynthesis
- DNA and Nucleic Acid Chemistry
- Synthesis and Catalytic Reactions
- Synthesis of Organic Compounds
- Marine Biology and Environmental Chemistry
- Natural product bioactivities and synthesis
- Steroid Chemistry and Biochemistry
- Supramolecular Chemistry and Complexes
- Analytical Chemistry and Chromatography
- Biochemical and Structural Characterization
- Monoclonal and Polyclonal Antibodies Research
- Traditional and Medicinal Uses of Annonaceae
- Chemical Synthesis and Reactions
- Phytochemical compounds biological activities
- Supramolecular Self-Assembly in Materials
University of Salerno
2016-2025
Scripps Research Institute
1994-2018
European Synchrotron Radiation Facility
2013
Istituto di Chimica Biomolecolare
2006
National Agency for New Technologies, Energy and Sustainable Economic Development
2006
Institute of Soil Science and Plant Cultivation
2001
State University of New York
1999-2000
Stony Brook University
2000
RINA Consulting - Centro Sviluppo Materiali S.p.A. (Italy)
1994-1997
University of Naples Federico II
1991-1996
l-Proline and N-methoxyethyl glycine have been included in novel cyclic hexameric peptoids. Supramolecular coordination with Na+ triggered the formation of first 1D metal–organic framework based on
Nine flavones and adenosine have been identified in aerial parts of alfalfa, their structures were established by spectral (FABMS NMR) techniques. Five the compounds, including apigenin 7-O-[β-d-glucuronopyranosyl(1→2)-O-β-d-glucuronopyranosyl]-4'-O-β-d-glucuronopyranoside, 7-O-[2-O-feruloyl-β-d-glucuronopyranosyl(1→2)-O-β-d-glucuronopyranosyl]-4'-O-β-d-glucuronopyranoside, 7-O-{2-O-feruloyl-[β-d-glucuronopyranosyl(1→3)]-O-β-d-glucuronopyranosyl(1→2)-O-β-d-glucuronopyranoside},...
Abstract A novel synthetic approach to the construction of zaragozic acids, which was used for asymmetric synthesis acid A/squalestatin S1 ( 1 ), is described. Fragment 5 , representing tricarboxylic core portion, assembled in three key steps: 1) Stille coupling establish carbon framework; 2) enantioselective dihydroxylation introduce absolute stereochemistry; and 3) diastereoselective complete required carbon‐oxygen connectivity. The convergency this demonstrated by dithiane addition a...
Pairing up: Oligodipeptide, oligodeoxydipeptide, or oligodipeptoid backbones tagged with the 2,4-diaminotriazine nucleus pair strongly complementary DNA and RNA. This is in sharp contrast behavior of 2,4-dioxotriazine nucleus, which does not act as a nucleobase these systems. Supporting information for this article available on WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z603207_s.pdf from author. Please note: The publisher responsible content functionality any supporting...
N-Benzyloxyethyl cyclic α-peptoids of various size were prepared and their conformational features investigated by means computational, spectroscopic, X-ray crystallographic studies.
Azumamide E, a cyclotetrapeptide isolated from the sponge Mycale izuensis, is most powerful carboxylic acid containing natural histone deacetylase (HDAC) inhibitor known to date. In this paper, we describe design and synthesis of two stereochemical variants product. These compounds have allowed us clarify influence side chain topology on HDAC-inhibitory activity. The present contribution also reveals identity recognition pattern between azumamides deacetylase-like protein (HDLP) model...
The synthesis, complexation properties and catalytic activities under phase-transfer (PT) conditions of differently substituted cyclohexapeptoids are reported. Association constants, for small cationic alkali, performances, in a model nucleophilic substitution, comparable to those representative crown ethers. Noteworthy, the N-[2-(2-methoxyethoxy)ethyl] side chain derivative presents efficiency that crypt-222, higher than some commonly used quaternary ammonium salts Moreover its association...
Abstract A series of cyclopeptoid‐based iminosugar clusters has been evaluated to finely probe the ligand content‐dependent increase in α‐mannosidase inhibition. This study led largest binding enhancement ever reported for an enzyme inhibitor (up 4700‐fold on a valency‐corrected basis), which represents substantial advance over multivalent glycosidase inhibitors previously reported. Electron microscopy imaging and analytical data support, best effects, formation strong chelate complex two...
The effects of substituents and cavity size on catalytic efficiency proline-rich cyclopeptoids under phase-transfer conditions were studied. High affinity constants (Ka) for the sodium potassium cations, comparable to those reported crown ethers, observed an alternated N-benzylglycine/L-proline hexameric cyclopeptoid. This compound was found catalyze alkylation N-(diphenylmethylene)glycine cumyl ester in values enantioselectivities with Cinchona alkaloid ammonium salts derivatives (83-96%...
In cyclic alpha-peptoids, inter-annular CH⋯OC hydrogen bonds provide face to or side by arrangement of macrocycles mimicking the beta-sheet secondary structure in proteins. Side chains may promote formation peptoid nanotubes, acting as pillars among neighbouring macrocycles.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe gymnochromes: novel marine brominated phenanthroperylenequinone pigments from the stalked crinoid Gymnocrinus richeriFrancesco De Riccardis, Maria Iorizzi, Luigi Minale, Raffaele Riccio, Bertrand Richer de Forges, and Cecile DebitusCite this: J. Org. Chem. 1991, 56, 24, 6781–6787Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November...
N-Benzyloxyethyl macrocyclic peptoids 3 and 4 were synthesized subjected to alkali metal binding studies; these compounds, plus the known 1 2, when ion transport studies, demonstrated size-dependent selectivity for first group metals cation transport.
1,3-Alternate cationic calix[4]arene 1 proved highly selective for proton/halogens symport transport and showed antiproliferative activity against murine monocyte/macrophage J774.A1 cancer cells.
Two new cyclic hexapeptoids incorporating N-carboxyethylglycine and N-methoxyethylglycine residues are able to efficiently bind Gd(3+). Their thermodynamic stabilities relaxivities have been assessed by (1)H-relaxometric investigations.
Abstract The first application of cyclopeptoids in asymmetric phase‐transfer catalysis was examined. A small library nine alternating N ‐substituted‐glycine and proline hexacyclopeptoids tested the enantioselective alkylation ‐(diphenylmethylene)glycine tert ‐butyl ester. presence an ‐arylmethyl side chain catalyst found to be crucial for synthesis α‐amino acids with up 73 % ee .
The introduction and development of neutral macrocyclic hosts capable complexing ions within their pre-organized cavity, has been utmost importance in supramolecular chemistry. Their ability to form stable organic-soluble metal–macrocycle complexes opened up the way application phase-transfer catalysis (PTC) as a viable alternative quaternary onium salts. In particular, conformationally rigid preorganized backbone, accommodating organic substrates defined orientations, promotes highly...
Cyclic N-propargyl α-peptoids of various sizes were prepared by way macrocyclizations linear N-substituted oligoglycines. These compounds used as molecular platforms to synthesize a series iminosugar clusters with different valency and alkyl spacer lengths means Cu(I)-catalysed azide-alkyne cycloadditions. Evaluation these α-mannosidase inhibitors led significant multivalent effects further demonstrated the decisive influence scaffold rigidity on binding affinity enhancements.
A peptidomimetic compound undergoes a reversible single-crystal-to-single-crystal transformation upon guest release/uptake with the involving drastic conformational change. The extensive and alteration in solid state is connected to formation of an unprecedented "CH-π zipper" which can reversibly open close (through CH-π interactions), thus allowing for sensing.
Peptoids ( N ‐substituted glycine oligomers) are an increasingly important class of peptidomimetic foldamers with conspicuous bioactivities, high degree resistance to enzymatic degradation, and ability form stable secondary structures. The intrinsic rigidity their oligoamide framework (due n →π*, side chains C α –H ··· O=C →σ*, backbone interactions), can be magnified by cyclization afford macrocyclic species unexpected stereochemical, topological biochemical attributes. In this minireview...