A5041280235- Cutaneous lymphoproliferative disorders research
- Genetic and rare skin diseases.
- Tumors and Oncological Cases
- Autoimmune Bullous Skin Diseases
- Nail Diseases and Treatments
- Vascular Malformations and Hemangiomas
- Histiocytic Disorders and Treatments
- Fungal Infections and Studies
- Cancer and Skin Lesions
- Dermatological diseases and infestations
- Vascular Tumors and Angiosarcomas
- Hedgehog Signaling Pathway Studies
- Eosinophilic Disorders and Syndromes
- RNA regulation and disease
- Acne and Rosacea Treatments and Effects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Genital Health and Disease
- CNS Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Skin and Cellular Biology Research
- Italian Literature and Culture
- T-cell and Retrovirus Studies
- Oral and Maxillofacial Pathology
- Dermatologic Treatments and Research
- Cutaneous Melanoma Detection and Management
Garrahan Hospital
2016-2025
University of Pennsylvania
2023
University of Ferrara
2011
Cutaneous skeletal hypophosphatemia syndrome (CSHS) is a mosaic RASopathy caused by postzygotic, activating pathogenic variants in HRAS, NRAS, or KRAS. It characterized congenital epidermal, melanocytic, sebaceous nevi, elevated FGF23 levels that cause renal phosphate wasting and rickets, focal bone lesions. We report 13-year-old girl with CSHS from Argentina. At 15 days old, she was presented an extensive epidermal nevus (pigmento-keratotic phacomatosis). She developed valgus deformity of...
Introduction: Lymphoma (NHL) patients (pts) relapsing/refractory (R/R) to anti-CD19 chimeric antigen receptor T-cells (CART) represent a challenging group in need of effective therapies. HuCART19-IL18 is 4th generation 4-1BB CART product designed express humanized CAR and secrete interleukin 18, pro-inflammatory cytokine shown enhance efficacy pre-clinical models. Its scFv may allow for better persistence, the additional use novel expedited 3-day manufacturing protocol improve product's...
Neonatal lupus erythematosus is a very rare disease, clinically characterized by skin lesions that resemble those of subacute or discoid and/or congenital heart block. Generally, when patients have manifestations, they no cardiac defects and vice-versa; however, in 10% cases these manifestations may coexist. Other findings include hematologic, hepatic neurological abnormalities. This condition caused the transplacental passage maternal autoantibodies against Ro (95%), La and, less...
Abstract Background The aim of this study was to determine the relative frequency primary cutaneous lymphoma (PCL) in Argentina according new World Health Organization (WHO)‐European for Research and Treatment Cancer (EORTC) classification system. Methods A total 416 patients from 21 dermatology services were included during a 5‐year period (2010–2015); these classified using WHO‐EORTC criteria. Results There 231 (55.2%) males 185 (44.8%) females; male‐to‐female ratio 1.35. median age 57...
Abstract Multifocal lymphangioendotheliomatosis with thrombocytopenia ( MLT ) is a rare disease characterized by congenital and progressive vascular lesions of the skin gastrointestinal tract that may be associated possibly life‐threatening bleeding. Reports published on treatment strategies are scarce. We present two cases treated sirolimus.
Polyarteritis nodosa is a rare vasculitis in children characterized by necrotizing inflammation small and medium size arteries. It classified into systemic cutaneous PAN according to the presence of symptoms or visceral involvement. We describe case 14-year-old girl with an atypical clinical presentation.
Nevoid basal cell carcinoma (BCC) syndrome, or Gorlin is a rare autosomal dominant disorder associated with mutations in the patched 1 gene, PTCH1. It characterized by presence of multiple BCCs association disorders affecting bones, skin, eyes, and nervous system. We describe 6 cases nevoid BCC syndrome evaluated our department. Palmoplantar pitting was observed all patients, 5 patients (83%), skeletal anomalies 3 (50%), odontogenic keratocysts patient (17%). would like to stress importance...
Mycosis fungoides (MF), the most common primary cutaneous T-cell lymphoma, is unusual in children. We aimed to describe epidemiologic, clinical, histopathologic, and immunophenotypic characteristics of MF as well treatments course disease a pediatric case series. Data for all patients admitted our hospital (Hospital Dr. J. P. Garrahan) Argentina with clinical histopathologic diagnosis between August 1988 July 2014 were included. A total 14 diagnosed MF. The ratio boys girls was 1:1.33. mean...
Presentación de casos clínicos RESUMENLa tungiasis es una parasitosis cutánea originaria América causada por Tunga penetrans.Se caracteriza lesiones papulares, negruzcas, únicas o múltiples, que suelen afectar los pies, principalmente en las zonas subungueales y periungueales.El diagnóstico se realiza características clínicas un paciente proveniente endémicas.El tratamiento elección la extracción quirúrgica pulga aplicación antibióticos tópicos.Presentamos caso 10 años edad con múltiples...
Tungiasis, is a cutaneous parasitosis, native of America caused by Tunga penetrans. Infestations usually presents with black papular lesions, either single or multiple, most them localized on the feet, mainly in subungual and periungual areas. Diagnosis tungiasis based characteristic aspect lesions patient coming from an endemic area. Surgical removal flea application topical antibiotic standard treatment. We describe case 10-years-old girl, multiple who was succesfully treated ivermectin...
Acquired postinfectious purpura fulminans is a rare, acute, and severe disease characterized by skin necrosis associated with disseminated intravascular coagulation (DIC) in the absence of active infection or previous disorders.It mainly affects pediatric population and, 90% cases, it preceded an infectious process.The pathophysiological mechanism transient autoantibodymediated protein S deficiency that favors hypercoagulable state.Here we describe case previously healthy 8-year-old boy...
Wells' syndrome, or eosinophilic cellulitis, is an inflammatory disease of unknown origin, uncommon in the pediatric age. It usually appears clinically as erythematous and edematous plaques, nodules, papules, blisters, among other symptoms. Here we describe case a female patient with generalized, asymptomatic subcutaneous nodules associated severe eosinophilia. The histopathological examination lesions was compatible syndrome. An interdisciplinary evaluation performed to establish cause look...
El granuloma anular (GA) es una dermatosis granulomatosa y benigna, de etiología desconocida. En los niños las formas clínicas más frecuentes son la localizada, que se presenta como placa eritematosa, anular, no escamosa; subcutánea, representada por un nódulo indoloro firme, compromete habitualmente miembros inferiores. adultos, el GA ha asociado a diabetes mellitus, pero existen pocos casos descriptos sobre esta asociación en pediatría. Se paciente 8 años edad, previamente sana, con...
Varón de 12 años consultó por una lesión localizada en la región occipital del cuero cabelludo que se extendía hacia cervical posterior y escapular derecha, un mes evolución. Al examen dermatológico observaba placa eritematosa con múltiples pústulas su superficie. A nivel derecho evidenciaba tumoración fluctuante dolorosa, secreción purulenta sobre misma descripta. La maniobra pilotracción era negativa. Hasta ese momento el paciente había recibido tratamientos corticoides, antibióticos...