A5040915893- Pancreatitis Pathology and Treatment
- Neuropeptides and Animal Physiology
- Invertebrate Immune Response Mechanisms
- Glioma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Hedgehog Signaling Pathway Studies
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Pancreatic function and diabetes
- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Receptor Mechanisms and Signaling
- Axon Guidance and Neuronal Signaling
- Viral Infectious Diseases and Gene Expression in Insects
- Glycosylation and Glycoproteins Research
- Signaling Pathways in Disease
- Gallbladder and Bile Duct Disorders
- Gastrointestinal Tumor Research and Treatment
- Trypanosoma species research and implications
- Hereditary Neurological Disorders
- Genomics and Phylogenetic Studies
- Vitamin K Research Studies
- Insect Resistance and Genetics
Heidelberg University
2006-2019
University of Tübingen
2012-2019
Deutschen Konsortium für Translationale Krebsforschung
2018-2019
Düsseldorf University Hospital
2017-2019
Heinrich Heine University Düsseldorf
2004-2019
German Cancer Research Center
2017-2019
Universitätsklinik für Chirurgie Wien
2015
Novartis (United States)
2012
Tris Pharma (United States)
2012
University of Veterinary Medicine Hannover, Foundation
2011
Endoscopic retrograde cholangiopancreatography (ERCP)-guided implantation of a biliary endoprosthesis or stent is the gold standard treatment for obstructions. When papilla cannot be traversed because there pyloric duodenal stenosis, catheter introduced, previous gastrointestinal surgery (Billroth II gastric resection, Whipple procedure, gastrectomy with Roux-en-Y reconstruction), alternative considered to percutaneous transhepatic cholangiography and drainage (PTCD). The aim study was...
Patients with mechanical obstruction of the pancreatic duct, which can be caused by chronic pancreatitis, suffer from recurrent attacks pain and inflammation pancreas. We report a novel approach using an endoscopic ultrasound- (EUS-) assisted rendezvous technique, allows drainage duct in patients whom primary management transpapillary during retrograde cholangiopancreatography (ERCP) procedure has failed. Transgastric puncture was performed 19-gauge needle under EUS guidance, 0.035-inch...
Multiplexins are multidomain collagens typically composed of an N‐terminal thrombospondin‐related domain, interrupted triple helix and a C‐terminal endostatin domain. They feature clear regulatory function in the development different tissues, which is chiefly conveyed by This domain can be found proteolytically released monomeric trimeric versions, their diverse opposed effects on migratory behavior epithelial endothelial cell types have been demonstrated culture experiments. The only...
Through a time period of 5 years, all consecutive patients were documented in this prospective single centre observational clinical study to investigate feasibility and outcome ultrasound(US)- EUS-guided drainage symptomatic non-infected pancreatic pseudocysts abscesses as well the endoscopic debridement infected necroses.From 03 / 23 2002 12 31 2008, 147 (females:males = 49:98 [1:2.0]) with (n 32), 81) necroses 34) enrolled study. Technical success rate US-guided external transmural was 100...
The present report summarizes rodent studies with vildagliptin, relevant to predicting pancreatitis or pancreatic cancer in man.As part of the regulatory development program for a toxicity included two 104-week (mouse and rat) carcinogenicity that were conducted according guidelines assigned Food Drug Administration's Draft Guidance Industry.Vildagliptin exposure animals was evaluated its effects on endocrine exocrine pancreas. Two-year rats at oral doses up 900 mg/kg (approximately 200...
Chitin produced by membrane-inserted chitin synthases is an important constituent of the arthropod cuticle and midgut peritrophic matrix. synthesis inhibitors are common insecticides in pest control. As target sulfonylurea-derived such as diflubenzuron, ABC transporter sulfonylurea receptor (Sur) has been postulated to be essential cofactor synthesis. However, direct evidence for this assumption missing.Here, a study made phenotype Drosophila melanogaster larvae suffering completely...
Navigation of motoneuronal growth cones toward the somatic musculature in Drosophila serves as a model system to unravel molecular mechanisms axon guidance and target selection. In large-scale mutagenesis screen, we identified piranha, motor mutant that shows strong defects neuromuscular connectivity pattern. piranha embryos, permanent defasciculation errors occur at specific choice points all pathways. Positional cloning revealed point mutations tolloid-related 1 (tlr1), an evolutionarily...
Ziel: Untersuchung des diagnostischen Stellenwerts der EUS-geführten FNP für solide und zystische Pankreastumore, tumorähnliche Läsionen als auch Metastasen in peripankreatischen Lymphknoten sowie ihren Einfluss auf den therapeutischen Entscheidungsprozess. Zytologische pathohistologische Untersuchungsergebnisse wurden verglichen mit: 1. -einander 2. Detektionsraten verschiedener Bildgebungsverfahren. Patienten Methoden: Insgesamt 153 (mittleres Alter: 56,9 Jahre) einer EUS-gestützten von I/...
Abstract The stability of extracellular matrices is in general ensured by cross-linking its components. Previously, we had shown that the integrity layered Drosophila cuticle relies on presence a covalent cuticular dityrosine network. Production and composition this structure remained unstudied. In work, present our analyses schlaff ( slf ) gene coding for putative C-type lectin needed adhesion between horizontal layers. Slf protein mainly localizes two layers called epicuticle procuticle...
Abstract HMGA2 is a major regulator of benign tumorigenesis from mesenchyme‐derived tissues and stem‐cell self‐renewal. It has been postulated that mediates its critical function by decreasing p16 Ink4a /p14 Arf expression cellular senescence. To repress the oncogenic activity HMGA2, lin‐28‐let‐7 axis thought to increasingly with age. understand HMGA2‐p14 ‐relationship in tumorigenesis, we performed series experiments on mesenchymal stem‐cells, i.e., proposed cells origin lipomas uterine...
Complications following endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) biopsy are rare. A 75-year-old man underwent EUS-FNA of an enlarged mediastinal lymph, which histologic investigation revealed to be a metastasis hepatocellular carcinoma. The patient developed the postinterventional complication suppurative infection within mediastinum. Under EUS guidance, pigtail catheter and soft tube were inserted respectively drain rinse lesion for 8 days. remaining esophagomediastinal...
Gastrointestinal (GI) tract bleeding, in particular originating within the long segment of small intestine, remains a diagnostic and therapeutic challenge. The authors describe potential utility emergency double balloon enteroscopy (DBE) for bowel bleeding. An elderly woman was admitted because hypertensive crisis to medical department regional hospital. Her history significant non-steroidal anti-inflammatory drug (NSAID) abuse. While hospital she had massive obscure GI Upper endoscopy...
Ziel: Ziel der Studie war, den diagnostischen Stellenwert US-gestützten perkutanen Punktion bei suspekten GI-Tumorläsionen, ermittelt durch abdominalen US, jedoch ohne endoskopischen Nachweis bzw. inkompletter oder nicht möglicher Endoskopie, zu untersuchen. Patienten und Methoden: Über einen definierten Zeitraum wurden alle konsekutiven entsprechende endoskopische Diagnostik, Probe Befund registriert. Patienten- diagnostikassoziierte als auch periinterventionelle Charakteristika...
Introduction: The death-associated protein kinase (DAPK) gene is a promoting regulator of programmed cell death and frequently inactivated by promotor methylation in many tumor entities.