A5025555838- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Water Quality Monitoring Technologies
- Hydrological Forecasting Using AI
- Water Quality and Pollution Assessment
North-West University
2023-2024
Rhodes University
2021
Abstract Kinetoplastids are a group of flagellated protozoans including medically important parasites the genus Trypanosoma and Leishmania . The corresponding diseases have afflicted humans for centuries. In an effort to combat kinetoplastid infections, set 21 chalcones was synthesized evaluated their in vitro anti-protozoal efficacy against brucei , rhodesiense cruzi infantum To ensure safety, these compounds underwent selectivity evaluation by assessing toxicity human lung fibroblast cell...
Reliable prediction of water quality changes is a prerequisite for early pollution control and vital in environmental monitoring, ecosystem sustainability, human health. This study uses Artificial Neural Network (ANN) technique to develop the best model fits predict parameters by employing multilayer perceptron (MLP) neural network radial basis function (RBF) network, using data collected from three district municipalities. Two input combination models, MLP-4-5-4 MLP-4-9-4, were trained,...
Trypanosomes and Leishmania are parasitic protozoans that affect millions of people globally. Herein we report the synthesis 2-aroyl quinazolinones their antiprotozoal efficacy against Trypanosoma brucei, brucei rhodesiense, cruzi, infantum. These compounds were counter-screened a human cell line for cytotoxicity. Thirteen twenty target in this study inhibited growth these parasites, with KJ1, KJ10 exhibiting IC50 values 4.7 μM (T. b. brucei) 1.1 rhodesiense), respectively.