A5019067697- Cancer-related Molecular Pathways
- Cervical Cancer and HPV Research
- interferon and immune responses
- Microtubule and mitosis dynamics
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
Leipzig University
2017-2021
Abstract Ki-67 serves as a prominent cancer marker. We describe how expression of the MKI67 gene coding for is controlled during cell cycle. mRNA and protein are maximally expressed in G 2 phase mitosis. Expression dependent on two CHR elements one CDE site promoter. DREAM transcriptional repressor complexes bind to both sites downregulate 0 /G 1 cells. Upregulation transcription coincides with binding B-MYB-MuvB FOXM1-MuvB from S into /M. Importantly, B-MYB correlates loss CHR-dependent...
Abstract High risk human papilloma viruses cause several types of cancer. The HPV oncoproteins E6 and E7 are essential for oncogenic cell transformation. mediates the degradation tumor suppressor p53, can form complexes with retinoblastoma pRB suppressor. Recently, it has been shown that also interfere function DREAM transcriptional repressor complex. Disruption DREAM-dependent repression leads to untimely early expression central cycle regulators. p53-p21-DREAM pathway represents one...
Abstract Most human cancers acquire mutations causing defects in the p53 signaling pathway. The tumor suppressor becomes activated response to genotoxic stress and is essential for arresting cell cycle facilitate DNA repair or initiate apoptosis. p53-induced cycle-arrest mediated by expression of CDK inhibitor p21WAF1/Cip1, which prevents phosphorylation inactivation pocket proteins RB, p130, p107. In a hypophosphorylated state, bind E2F factors forming RB-E2F DREAM transcriptional repressor...