A5071517009- interferon and immune responses
- Neurogenesis and neuroplasticity mechanisms
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Immune cells in cancer
Southern Medical University
2021-2022
Plenty of macrophages are recruited to the injured nerve play key roles in immunoreaction and engulf debris degenerated axons myelin during Wallerian degeneration, thus creating a conducive microenvironment for regeneration. Recently, drugs targeting RhoA pathway have been widely used promote peripheral axonal However, role macrophage degeneration regeneration after injury is still unknown. Herein, we come up with hypothesis that might influence by affecting migration phagocytosis...
(1) Background: the miR-301a is well known involving proliferation and migration of tumor cells. However, role in phagocytosis macrophages still unclear. (2) Methods: sciatic nerve injury, liver injury models, as primary macrophage cultures were prepared from knockout (KO) wild type (WT) mice to assess macrophage’s capabilities. Targetscan database analysis, Western blotting, siRNA transfection, CXCR4 inhibition or activation performed reveal miR301a’s potential mechanism. (3) Results:...