Purpose: Malnutrition is highly prevalent in critically ill patients and associated with the increased healthcare-related cost poor patient outcomes. Identifying factors undernutrition may assist nutritional care. Therefore, this study was designed to identify malnutrition inadequate energy intake improve support intensive care unit (ICU). Methods: This prospective conducted on 285 random samples of ICU patients. We reported time initiate enteral nutrition, percent adequately received...

Pressure ulcer (PrU)-related hospitalisation and mortality are critical issues in medical surgical patients. Although animal studies have suggested the beneficial effects of sildenafil on wound healing, related clinical data lacking. This is first study that has evaluated topical PrU healing human subjects. Enrolled patients were randomly allocated to receive (10%) ointment or placebo daily. Wound was assessed visually photographically by change score according two-digit Stirling scale....

Study Objective To evaluate the effects of topical atorvastatin on healing process pressure ulcers in critically ill patients. Design Randomized, double-blind, placebo-controlled clinical trial. Setting Medical-surgical intensive care unit a university-affiliated teaching hospital Tehran, Iran. Patients One hundred four patients with stage I or II ulcers, graded according to 2-digit Stirling Pressure Sore Severity Scale. Intervention were randomized receive 1% ointment (51 [atorvastatin...

Objective: To evaluate the effectiveness of oral N-acetylcysteine (NAC) co-treatment in preventing amphotericin B (AmB)-induced nephrotoxicity (AIN), including creatinine clearance and biomarkers renal function (cystatin C [Cys C] kidney injury molecule-1 [KIM-1]).Methods: Either placebo or 600 mg NAC was given twice daily during treatment course AmB. Renal test, serum as well urinary level Cys KIM-1 were determined.Results: Among study population (n = 54), 23 (42.59%) patients developed AmB...

Concern about adverse effects of the inconsistent use stress-related mucosal damage prophylaxis in intensive care unit (ICU) is increasing. Hence, this study was designed to prospectively evaluate rate inappropriate stress ulcer (SUP) administration upon ICU admission, at discharge and determine adherence American Society Health-System Pharmacists (ASHP) guideline during stay.In study, 200 patients were randomly selected from all admissions 9 months. Risk factors recorded daily stay...

In this study, gelatin/hyaluronic acid (HA) scaffolds containing different amounts of atorvastatin-loaded nanostructured lipid carriers (NLCs) coated entirely with polycaprolactone (PCL) film were fabricated for skin regeneration. 12 NLCs formulations synthesized, and particle size, zeta potential, drug entrapment efficiency (EE), release the determined. The optimum freeze-dried added in 3 weight percentages to gelatin HA membranous scaffolds. Thereafter, membranes by a thin layer PCL. They...

Previous research showed some clinical benefits regarding the nephroprotective effect of melatonin. So, this study aimed to evaluate beneficial oral melatonin on preventing acute kidney injury (AKI) in patients who received vancomycin therapy intensive care unit (ICU).We performed a randomized, double-blinded, placebo-controlled pilot an academic hospital. Adult admitted ICU with normal gastrointestinal and function were randomized into treatment or placebo groups. After that, enrolled...

Purpose:The dramatic increase in stress ulcer prophylaxis (SUP) prescribing patterns over the past several years has raised concerns regarding to their appropriate utilization.This prospective study attempted evaluate trend of adherence from admission until discharge non-Intensive care unit (ICU) setting.Additionally, we find those variables associated with SUP administration.Methods: Data collection was performed prospectively 195 randomly selected adult patients who received or had...

This study aimed to prepare, optimise, and characterise the novel hybrid hydrogel scaffold containing atorvastatin lipid nanocapsules (LNCs) gold nanoparticles (NPs) improve cardiomyoblasts proliferation regeneration of myocardium. A thermo-responsive aminated guaran (AGG) was prepared encompass extracellular matrix (ECM) fetched from human adipose tissue. Emulsion phase-inversion technique used obtain LNCs. Biocompatibility, tensile strength, conductivity, myocardial cells optimised...

Background: Elderly patients are susceptible to post-induction hypotension. Volume loading and vasopressors for prevention of hypotension in elderly may increase perioperative cardiovascular risks. Ondansetron by blocking Bezold-Jarisch reflex (BJR) through inhibition serotonin receptors has been effective the post-spinal hypotension, bradycardia. Bradycardia frequently accompanies patients, which signifies a possible preventing role ondansetron. No previous study evaluated prophylactic...

Management of difficult to wean patients is a dilemma for health care system. Recently published studies demonstrated efficacy donepezil counteract respiratory depression in sleep apnea. However, the best our knowledge, pharmaceutical interventions with facilitate weaning have not been tested so far. Therefore present study, we evaluated using on course patients.In this non-randomized interventional clinical prior inappropriately depressed responses were included from two referral intensive...

Introduction: Hyperglycemia is one of the most frequent metabolic complications in hospitalized patients. Increased risk infection following hyperglycemia has been reported patients and infections may also cause insulin resistance which complicates control blood glucose level. In this study impact clinical pharmacist interventions on glycemic admitted to infectious diseases ward evaluated. Methodology: We conducted a prospective, pre-post interventional among with hyperglycemia. The...