A5004425900- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Chemical Synthesis and Reactions
- Radical Photochemical Reactions
- Oxidative Organic Chemistry Reactions
- Synthesis and Catalytic Reactions
- Carbon dioxide utilization in catalysis
- Fluorine in Organic Chemistry
- Sulfur-Based Synthesis Techniques
- Cyclopropane Reaction Mechanisms
- Ionic liquids properties and applications
- Luminescence and Fluorescent Materials
- Organometallic Complex Synthesis and Catalysis
- Synthesis and Characterization of Pyrroles
- Analytical chemistry methods development
- Synthesis of Indole Derivatives
- Synthesis and Biological Evaluation
- CO2 Reduction Techniques and Catalysts
- Biochemical and biochemical processes
- Lanthanide and Transition Metal Complexes
- Asymmetric Synthesis and Catalysis
- Molecular Sensors and Ion Detection
- Inorganic Fluorides and Related Compounds
- Phosphorus compounds and reactions
- Asymmetric Hydrogenation and Catalysis
OmegaChem (Canada)
2020
Institut Charles Gerhardt Montpellier
2015-2019
École Nationale Supérieure de Chimie de Montpellier
2015-2019
Université Laval
2013-2019
Centre National de la Recherche Scientifique
2014-2019
Ruhr University Bochum
2016-2018
École Normale Supérieure - PSL
2014
The α-arylation of enolizable aryl ketones can be carried out with halides under transition-metal-free conditions using KOtBu in DMF. α-aryl thus obtained used for step- and cost-economic syntheses fused heterocycles Tamoxifen. Mechanistic studies demonstrate the synergetic role base solvent initiation radical process.
A carboxylate-directed ortho-C-H functionalization has been developed and it allows the regiospecific introduction of allyl residues to benzoic acids. In presence a [Ru(p-cymene)Cl2 ]2 K3 PO4 , acids react with acetates at only 50 °C give corresponding ortho-allylbenzoic The protocol is generally applicable both electron-rich electron-poor in combination linear branched acetates. products can be further functionalized situ, for example, by double-bond migration, lactonization, or decarboxylation.
Abstract The α‐arylation of enolizable aryl ketones can be carried out with halides under transition‐metal‐free conditions using KO t Bu in DMF. α‐aryl thus obtained used for step‐ and cost‐economic syntheses fused heterocycles Tamoxifen. Mechanistic studies demonstrate the synergetic role base solvent initiation radical process.
Abstract In the presence of a bimetallic Pd/Cu system with 1,10‐phenanthroline as ligand and either air or N ‐methylmorpholine ‐oxide oxidant, electron‐deficient benzoic acids undergo oxidative decarboxylative coupling unprotected amines. This operationally simple aniline synthesis is widely applicable respect to amine gives good yields, even on multigram scale. The orthogonality this reaction other Pd‐catalyzed cross‐couplings allows concise multisubstituted arenes by sequential C−C, C−Cl,...
A study on the arylation of heteroatom nucleophiles by using activated haloarenes, with or without metal catalysts, is reported. discussion concerning involvement traces metals presented, supported an unexpected ''ligand'' effect in absence added catalysts. We believe that frontier between nucleophilic aromatic substitution and catalysis will likely prove to be much harder delimit than generally thought.
Abstract A carboxylate‐directed ortho ‐C−H functionalization has been developed and it allows the regiospecific introduction of allyl residues to benzoic acids. In presence a [Ru( p ‐cymene)Cl 2 ] K 3 PO 4 , acids react with acetates at only 50 °C give corresponding ‐allylbenzoic The protocol is generally applicable both electron‐rich electron‐poor in combination linear branched acetates. products can be further functionalized situ, for example, by double‐bond migration, lactonization, or...
An α-vinylation of enolizable ketones has been developed by using β-bromostyrenes and a KOtBu/NMP system. β,γ-Unsaturated E configuration were obtained in excellent yield selectivity. Further synthetic possibilities are highlighted one-pot functionalization via trapping intermediate dienolates with alkyl, allyl, benzyl, propargyl halides to generate quaternary centers. The reported transformation is believed involve phenylacetylene propargylic alcohol derivatives.
An original metal-free procedure for the synthesis of biarylmethanes is disclosed herein. The reactions occur with high selectivity starting from aryl iodides and benzylic ketones in presence superbasic media (CsOH/DMSO). This allows a straightforward access to wide range biarylmethane derivatives substituted electron-withdrawing -donating substituents.
Various aryl ketones are efficiently transformed via the reaction with aryliodides, bromides, and chlorides.