A5070245624- Traumatic Brain Injury and Neurovascular Disturbances
- Hemoglobin structure and function
- Analytical Chemistry and Chromatography
- Drug Solubulity and Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Crystallization and Solubility Studies
- Intracranial Aneurysms: Treatment and Complications
- Asthma and respiratory diseases
- Hepatitis C virus research
- Environmental Monitoring and Data Management
- High Altitude and Hypoxia
- Computational Physics and Python Applications
- Chemical Thermodynamics and Molecular Structure
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiovascular and Diving-Related Complications
- Diagnosis and Treatment of Venous Diseases
- Central Venous Catheters and Hemodialysis
- Intramuscular injections and effects
- Acute Ischemic Stroke Management
- Gastrointestinal motility and disorders
- Thermal and Kinetic Analysis
- Anesthesia and Sedative Agents
- Analytical Methods in Pharmaceuticals
- Experimental and Theoretical Physics Studies
- Helicobacter pylori-related gastroenterology studies
NuvOx Pharma (United States)
2009-2024
Tucson Medical Center
2016-2017
University of Arizona
2002-2011
Harper University Hospital
2011
The purpose is to prepare 2% w/v emulsions of dodecafluoropentane, perfluorodecalin, and perfluoroctylbromide compare them for their ability absorb oxygen.The oxygen uptake capability volume expansion each emulsion the blank vehicle were evaluated in water at 21°C 37°C. average particle size dodecafluoropentane < 400 nm stored room temperature 6 months. In comparison treated with either vehicle, perfluorodecalin emulsion, or absorbs 3 times more 7 Furthermore, a significantly higher vitro (5...
Tumor hypoxia is an important mediator of radiation therapy resistance.We conducted a study to investigate whether oxygen therapeutic based upon dodecafluoropentane (DDFP) nanoemulsion (NVX-108) could increase tumor pO 2 in hypoxic tumors and improve response.Pancreatic (Hs-766T) xenografts were grown the flanks 29 SCID mice.Direct measurements performed 9 mice treated with 0.3, 0.45 0.6 cc/kg NVX-108 (2% w/vol DDFP) order assess dose dependent .Twenty randomized into 3 groups including...
The prediction of the entropy fusion organic compounds is studied. Rotational symmetry (σ) and flexibility (φ) have already been shown to contribute orientational conformational fusion, respectively. Eccentricity (ε) spirality (μ) are two new parameters that influence translational configurational entropy. ε defined as ratio volume a box around rigid molecule cubed radius sphere containing same molecular van der Waals volume. μ number benzo[c]phenanthrene regions present in molecule. This...
A three-dimensional model of the water molecule was developed for purpose simulating some properties and ice. Four cylindrical dipole magnets were inserted secured into small spheres at angles 109.5° from each other. The north poles represent hydrogen atoms south lone electron pairs oxygen. models can be used to demonstrate water, such as formation ice lattice, melting under pressure, squeezing out nonpolar molecules in mixtures, flickering clusters proposed by Frank Wen 1957. These...
Introduction: Neuroprotective strategies in ischemic stroke include oxygen delivery to sustain penumbra and prevent hypoxic cell death. Hyperbaric oxygen, blood substitutes, liquid fluorocarbon-based carriers have often failed treatment of other disorders. Dodecafluoropentane emulsion (DDFPe, boiling point 29°C) shifts quasi-gas phase at body temperature, which allows absorption transportation very high levels oxygen. Exceptionally small particle size, 250-300 nm, may allow even through...
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTThree-Dimensional Model for Water: Magnets as Dipoles (the authors reply)Samuel H. Yalkowsky and Jennifer L. Johnson View Author Information Department of Pharmaceutical Practice Science, University Arizona, Tucson, AZ 85721Cite this: J. Chem. Educ. 2004, 81, 1, 34Publication Date (Web):January 2004Publication History Received3 August 2009Published online1 January 2004Published inissue 1 2004https://doi.org/10.1021/ed081p34.2RIGHTS &...
Introduction: Intravenous dodecafluoropentane emulsion (DDFPe) has proven ability to transport oxygen in ischemic and anemic animal models. Therapeutic effects rabbits pigs last at least 90 minutes, although human studies (DDFP) is eliminated rapidly from the blood through respiration. DDFPe neuroprotection reduces infarct volumes >80% our rabbit embolic stroke model. Since little known about activity rabbits, pharmacokinetics were investigated healthy determine dosing regimens....