A5012557527- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Hemoglobinopathies and Related Disorders
- Blood groups and transfusion
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal Transplantation Outcomes and Treatments
- Iron Metabolism and Disorders
Maulana Azad Medical College
2019-2021
University of Delhi
2019-2021
Johns Hopkins Medicine
2019
Johns Hopkins University
2019
Abstract Background Thrombotic thrombocytopenic purpura (TTP) is a life‐threatening disorder characterized by thrombocytopenia, microangiopathic hemolysis, and ischemic organ failure. The PLASMIC French TTP scores can help guide clinical decisions when ADAMTS13 testing not immediately available. Older individuals often present atypically, but the impact of age on these tools known. Study Design Methods We calculated sensitivity specificity in patients enrolled Johns Hopkins thrombotic...
Terminal complement inhibition is the standard of care for atypical hemolytic uremic syndrome (aHUS). The optimal duration unknown, although indefinite therapy common. Here, we present outcomes a physician-directed eculizumab discontinuation and monitoring protocol in prospective cohort 31 patients that started acute aHUS (and without history renal transplant). Twenty-five (80.6%) discontinued after median on 2.37 (interquartile range: 1.06, 9.70) months. Eighteen per 7 because nonadherence....