A5053087918- Ocular Oncology and Treatments
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Cancer-related Molecular Pathways
- Acute Lymphoblastic Leukemia research
- Toxoplasma gondii Research Studies
- Phagocytosis and Immune Regulation
- interferon and immune responses
- CNS Lymphoma Diagnosis and Treatment
- Retinopathy of Prematurity Studies
- Advanced Breast Cancer Therapies
- Vitamin D Research Studies
- Glioma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Retinoids in leukemia and cellular processes
- Corneal Surgery and Treatments
- History of Medicine Studies
- Childhood Cancer Survivors' Quality of Life
- Retinal and Optic Conditions
- Angiogenesis and VEGF in Cancer
- Empathy and Medical Education
- Nuclear Receptors and Signaling
- Cancer Immunotherapy and Biomarkers
- Retinal and Macular Surgery
- Parkinson's Disease and Spinal Disorders
Sidney Kimmel Cancer Center
2019-2022
Thomas Jefferson University
2020
ORCID
2019
University of Tennessee Health Science Center
2017-2019
Cincinnati Eye Institute
2017
Pennsylvania State University
2017
Purpose: Vitreous seeding remains the primary reason for treatment failure in eyes with retinoblastoma (Rb). Systemic and intra-arterial chemotherapy, each its own inherent set of complications, have improved salvage rates advanced disease, but location biology vitreous seeds present a fundamental challenge developing treatments minimal toxicity risk. The aim this study was to target platelet-derived growth factor (PDGF)– PDGF-receptor β (PDGFRβ) signaling pathway investigate role Rb seeds,...
Growing evidence attests to the vital role vitamin D plays in dynamics of immune system.Active 1,25(OH)2D3 binds receptor (VDR) form a ligand-activated complex able control transcription nucleus.We examined various mechanisms through which D3 alters and enhances responses variety skin conditions, as well pathways it activates inhibit progression tumors carcinomas.The hormone primarily elicits change either an inflammation modulator or cancer suppressor.Also addressed are current advancements...
Methotrexate (MTX) a folate antagonist is often given in high doses (≥500 mg/m2) to treat variety of disease processes. While inpatient administration has been the norm, outpatient administration, shown be safe, effective, and patient centered. Here we describe development an HDMTX protocol our initial experience.All patients were receive their first cycle hospital ensure they tolerate it well also use this time assist training for home administration. The involved continuous IV sodium...
PurposeThe liver is the most common site of uveal melanoma (UM) metastasis with approximately 50% UM patients being affected.With no proven therapies that mitigate metastases mortality rate 85% within first year after detection disease.In this study, we provide a mechanistic understanding de-regulation TP53-MDM2 pathway in UM, which plays central role tumor biology. MethodsWe investigated signaling microenvironment taken from both murine orthotopic xenograft and post-mortem metastatic human...
In the face of lost battles, long hours, and daunting challenges in medicine, it is easy to overlook happy endings leaps progress. many cases, doctor patient are both blips each other’s lives—the merely another name on rounding list; hospital nothing more than an interruption patient’s daily routine. At hospital, two worlds brush paths then cleanly separate after treatment. As a first-year medical student accustomed poring over textbooks diagrams, I often forgot about impact could one day...