A5064021286- Gut microbiota and health
- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cancer Cells and Metastasis
- Chemical Reactions and Isotopes
Oregon Health & Science University
2022-2024
The tumor microbiota has emerged as a pivotal contributor to variety of cancers, impacting disease development, progression, and therapeutic resistance. Due the complexity microenvironment, reproducing interactions between microbes, cells, immune system remains great challenge for both in vitro vivo studies. To this end, significant progress been made toward leveraging tumor-on-a-chip model systems replicate critical hallmarks native . These microfluidic platforms offer ability mimic...
Abstract Gut microbiome composition is tied to diseases ranging from arthritis cancer depression. However, mechanisms of action are poorly understood, limiting development relevant therapeutics. Organ‐on‐chip platforms, which model minimal functional units tissues and can tightly control communication between them, ideal platforms study these relationships. Many gut models published date but devices typically fabricated using oxygen permeable polydimethylsiloxane, requiring interventions...
Abstract Gut microbiome composition has been tied to diseases ranging from arthritis cancer depression. However, mechanisms of action are poorly understood, limiting development relevant therapeutics. Organ-on-chip platforms, which model minimal functional units tissues and can tightly control communication between them, ideal platforms study these relationships. Many gut models have published date but devices typically fabricated using oxygen permeable PDMS, requiring interventions support...
Abstract Gut microbiota are recognized as an integral part in maintaining health, with disturbances composition linked to disease states ranging from cancer depression. Breast patient microbiome analysis has demonstrated a correlation between dysbiosis and proposed mechanisms including immune cell regulation, enhanced inflammatory signaling, modulation of estrogen metabolism through the estrobolome. Current models lack ability study communication one direction or modulate single variables...