A5103144225- Schizophrenia research and treatment
- Neuroendocrine regulation and behavior
- Bipolar Disorder and Treatment
- Sleep and related disorders
- Diet and metabolism studies
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Tryptophan and brain disorders
- Evolutionary Psychology and Human Behavior
- Regulation of Appetite and Obesity
- Growth Hormone and Insulin-like Growth Factors
- Occupational Health and Performance
- Resilience and Mental Health
- Attention Deficit Hyperactivity Disorder
- Paraoxonase enzyme and polymorphisms
- Fatty Acid Research and Health
- Gastroesophageal reflux and treatments
- Alcoholism and Thiamine Deficiency
- Infant Health and Development
- Personality Disorders and Psychopathology
- Treatment of Major Depression
- Receptor Mechanisms and Signaling
- Enhanced Oil Recovery Techniques
- Transcranial Magnetic Stimulation Studies
- Menopause: Health Impacts and Treatments
Taipei Medical University
2019-2025
Wan Fang Hospital
2019-2025
Fırat University
2013
Background: Dysfunction of the N-methyl- D-aspartate glutamate receptor is involved in putative pathology schizophrenia. There growing interest potential modulators to improve symptoms schizophrenia, but evidence for use glutamatergic agents augmenting schizophrenia remains inconclusive. Aims: We conducted a meta-analysis test efficacy and safety modulator supplements patients with Methods: Following systemic search MEDLINE, Embase, Cochrane Scopus, 40 double-blinded, randomised,...
Abstract Childhood trauma has been linked to schizophrenia, but underlying biological mechanisms remain elusive. This study explored the potential role of plasma oxytocin as a mediator in relationship between childhood and psychopathology schizophrenia. 160 patients with schizophrenia 80 age- sex-matched healthy controls were assessed for experiences using Trauma Questionnaire structured interviews. Psychopathology was evaluated Positive Negative Syndrome Scale levels measured. Results...
Background: Several monotherapy and augmentation strategies have been introduced to improve the treatment of schizophrenia. The benefits omega-3 polyunsaturated fatty acids in patients with mental disorders is becoming increasingly acknowledged. However, its role schizophrenia raises complex considerations about which there has little consensus. aim this study was synthesize findings randomized controlled trials that were conducted determine efficacy safety Methods: MEDLINE, Embase,...
Theta-burst stimulation is a non-invasive brain technique that was introduced as potential augmentation treatment for patients with schizophrenia. The purpose of this meta-analysis to investigate the therapeutic efficacy and safety intermittent theta-burst in Following PRISMA guidelines, MEDLINE, Embase, Cochrane, Scopus, Web Science, CNKI databases were searched relevant studies from database inception 9 January 2022. Change symptom severity among schizophrenia primary outcome, changes...
Objective: Therapeutic drug monitoring (TDM) indicators have been suggested to predict overall outcome responses olanzapine (OLZ) treatments in terms of efficacy and metabolic syndrome. This study aimed investigate whether paraoxonase-1 (PON-1) activity can be used schizophrenia patient outcomes. Methods: Schizophrenic patients ( N = 50) aged between 20 65 years who received OLZ treatment were recruited, their Positive Negative Syndrome Scale scores, PON-1 activity, levels normalized by dose...
Abstract Background Clozapine stands as the drug of choice for treating individuals with treatment-resistant schizophrenia (TRS). However, only 40% patients TRS respond to clozapine, forming a subgroup clozapine- resistant patients. Recently, neuropeptide orexin-A has emerged its relevance in pathophysiology (Chien et al., 2015) and higher levels been found treated clozapine compared drug-free (Chen 2022). Aims & Objectives This study aimed evaluate association between peripheral...
Abstract Background Prolactin elevation, resulting from dopamine D2 receptor antagonism, is a common side effect of antipsychotic medications. Olanzapine, an atypical drug, offers enhanced clinical efficacy and fewer effects compared to typical drugs. Nevertheless, some studies suggest that olanzapine may still lead increase in prolactin levels. Aims & Objectives Our study aimed explore the potential metformin managing olanzapine- induced hyperprolactinemia patients with schizophrenia....
Background: Antipsychotic treatment is commonly associated with hyperprolactinemia, leading to menstrual disturbances, sexual dysfunction, and decreased bone mineral density. Nearly all antipsychotic drugs can elevate prolactin levels, affecting up 70% of patients schizophrenia. We aim evaluate the potential therapeutic role metformin in reducing hyperprolactinemia among these patients. Methods: systematically searched PubMed, CNKI, Embase, Cochrane, Web Science through January 31, 2024, for...
Background: Clozapine is the primary antipsychotic (APD) for treatment-resistant schizophrenia (TRS). However, only 40% of patients with TRS respond to clozapine, constituting a subgroup clozapine-resistant patients. Recently, neuropeptide orexin-A was shown be involved in pathophysiology schizophrenia. This study evaluated association levels clozapine response TRS. Methods: We recruited 199 schizophrenia, including 37 APD-free and 162 clozapine-treated Clozapine-treated were divided into...
The lymphocyte-related ratios, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR) and platelet-to-lymphocyte (PLR) are new measures of inflammation within the body. Few studies have investigated inflammatory response patients with methamphetamine-induced psychotic disorder. Clinically, symptoms behavioural manifestation disorder often indistinguishable from paranoid schizophrenia. We aimed to determine differences in these markers between disorder, schizophrenia healthy...
Schizophrenia is one of the most stigmatized mental disorders. In 2014, schizophrenia was renamed in Mandarin Taiwan, from old name “mind-splitting disease” to new “disorder with dysfunction thought and perception”, an attempt reduce stigmatization schizophrenia. This cross-sectional study aimed investigate effects renaming on its stigma nursing students. We examined public stigma, self-stigma, social distance associated compared them before after renaming. Basic demographic data previous...
Objectives Firefighters are exposed to repeated traumatic events while the robustness of cumulative effects exposure trauma on psychological distress among them inconsistent. Considering length service and seniority risk factors, purpose this study was examine interaction between age quality life firefighters. Methods Participants were 229 firefighters Hualien County Fire Bureau in Taiwan who worked full time response emergency services disaster rescues activities. Probable posttraumatic...
Orexin-A levels are reportedly increased in antipsychotic (APD)-treated patients with schizophrenia compared to healthy controls and have been associated metabolic abnormalities. It is not clear whether the orexin-A elevation related specifically drug (APDs) effect, which should be clarified by including a drug-free group for comparison, or drug-induced abnormalities.Blood profiles were between 37 drug-free, 45 aripiprazole-treated, 156 clozapine-treated schizophrenia. The association...
Evidence has demonstrated the association between childhood trauma and criminality in adulthood, however, less is known about how best to explain route from adulthood aggression. Results both human animal studies have generated hypothesis that dysfunction of oxytocinergic system may correlate with pathological The current study represents a first exploratory examination investigate trajectory aggression, specifically, plasma oxytocin's role this association. We assessed experiences total 108...
We aimed to evaluate the effects of folate and vitamin B12 on psychopathology in patients with schizophrenia low serum levels.
Schizophrenia is a chronic illness with worldwide lifetime prevalence of about 1% [1]. Non-adherence and partial adherence to antipsychotic medication treatment common long-acting injectable "depot" preparations medications have been used as an alternative oral therapy for patients whom clinically significant problem [2]. In present study,we collected the sociodemographic clinical data 252 who were diagnosed schizophrenia according DSM-IV-TR followed up by our outpatient clinic at least two...
Paliperidone extended-release (ER) is an atypical antipsychotic that presents the active metabolite of risperidone (9-hydroxyrisperidone) using OROS® technology [1]. Multinational placebo-controlled studies have shown paliperidone ER 3- 15 mg/day to be both efficacious and safe, with discontinuation rates due adverse events (AEs) similar placebo [2]. Seventy-eight female patients who were diagnosed as schizophrenia according DSM-IV-TR started on treatments or included present study. The...