A5046421930- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Immunodeficiency and Autoimmune Disorders
- Hemoglobinopathies and Related Disorders
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- DNA Repair Mechanisms
- Genomic variations and chromosomal abnormalities
- Chronic Myeloid Leukemia Treatments
- Neutropenia and Cancer Infections
- Iron Metabolism and Disorders
- Cytomegalovirus and herpesvirus research
- Neuroblastoma Research and Treatments
- Restless Legs Syndrome Research
- Oral health in cancer treatment
- Diabetes and associated disorders
- Cancer-related molecular mechanisms research
- Cellular transport and secretion
- Nonmelanoma Skin Cancer Studies
- Blood disorders and treatments
University of West Attica
2025
Children's Hospital Agia Sophia
2014-2024
National and Kapodistrian University of Athens
2006-2024
Earthquake Planning and Protection Organization
2018
University of Freiburg
2008-2010
Biomedical Research Foundation of the Academy of Athens
2009
University Medical Center Freiburg
2006-2008
University of Patras
2008
University Hospital of Basel
2001
Abstract PKC, Ras, and ERK1/2 signaling is pivotal to differentiation along the neuronal cell lineage. One crucial protein that may play a central role in this pathway Ras GTPase‐activating protein, neurofibromin, PKC substrate exert positive differentiation. In report, we studied dynamics of PKC/Ras/ERK signaling, during SH‐SY5Y neuroblastoma cells upon treatment with agonist, phorbol ester 12‐O‐tetradecanoyl‐phorbol‐13‐acetate (TPA). Surprisingly, observed that, among other PKC‐dependent...
The incidence of FLT3 mutations (internal tandem duplication and Asp835) was investigated in bone marrow samples from 97 patients with myelodysplastic syndrome [(MDS); excluding cases refractory anaemia excess blasts transformation] at the time diagnosis several points thereafter. Three had presentation. Forty-two progressed to acute myeloid leukaemia (AML), including three MDS diagnosis. additional acquired AML 1 month. seem be a critical genetic event that transforms minority AML.
Antifungal prophylaxis (AFP) is recommended in at-risk hematology-oncology patients. We evaluated the safety of AFP with voriconazole (VRC) pediatric hematology/oncology patients.A retrospective study VRC children malignancies hospitalized all 7 Greek centers during 2008 to 2012 was conducted. Patients' demographics, outcome, and adverse event (AE) data were recorded.Four hundred twenty-nine courses 249 patients (median age 6 y, 55% boys) studied. The most common underlying diseases acute...
We analyzed data on pediatric invasive fungal diseases of the central nervous system (CNS-IFDs) reported by five a total eight Pediatric Hematology-Oncology Departments in Greece for 16 years (2007–2022). A twelve patients (11 boys, median age: 9.5 years, range: 2–16) were suffering from CNS-IFDs. The underlying malignancy was acute lymphoblastic leukemia 9/12 and myeloid leukemia, Ewing sarcoma, rhabdomyosarcoma one each. Eleven presented with CNS-related symptoms (i.e., seizures, headache,...
Prognostic refinement in Fanconi anemia (FA) is needed, especially when considering allogeneic hematopoietic stem cell transplantation (HCT). We studied 20 children with FA and bone marrow failure from a single center. According to Hôpital Saint-Louis risk classification for FA, patients were classified stage A (no or mild cytopenia/dysplasia), B (single non-high-risk cytogenetic abnormality), C (severe cytopenia and/or significant dysplasia high-risk D (myelodysplastic syndrome excess of...
Background: Infections due to rare molds, such as Fusarium spp., cause severe and difficult-to-control diseases with increasing frequency. Data on fusariosis in children the use of voriconazole (VCZ), considered a drug choice, are scarce infants <2 years age. Case Presentation: We present first, our knowledge, pediatric case disseminated mycosis musae 15-month-old boy relapsed/refractory acute lymphoblastic leukemia, diagnostics outcome. Herein, at this severely immunocompromised patient,...
We performed IGH clonotypic sequence analysis in WM order to determine whether a preferential gene rearrangement was observed and assess IGHV mutational status blood and/or bone marrow samples from 36 patients. In addition we investigated the presence of MYD88 L265P somatic mutation. After VDJ locus amplification, monoclonal rearranged fragments were sequenced analyzed. mutation detected by AS-PCR. The most frequent family usage IGHV3 (74%); IGHV3-23 IGHV3-74 segments used 26% 17%,...
Abstract Aim Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia with diverse clinical behaviour. In this article, we studied the course, management and long‐term outcomes of a paediatric cohort treated by our reference centre. Methods We retrospectively 66 children LCH, consecutively diagnosed Greek centre from 1974 to 2020. Results The patients had median age 3.9 (range 0.0–15.9) years, 39 6 were unifocal or multifocal single system disease 14 7 multisystem without...
We analyzed data of pediatric invasive fungal diseases the central nervous system (CNS-IFDs) reported by five total eight Pediatric Hematology-Oncology Departments in Greece for 15 years (2007-2022). A twelve patients (11 boys, median age: 9.5yrs range: 2-16) were suffering from CNS-IFDs. Underlying malignancy was acute lymphoblastic leukemia 9/12, and myeloid leukemia, Ewing sarcoma rhabdomyosarcoma one each. Eleven presented with CNS-related symptoms (i.e seizures, headache, cerebral...
Abstract Aim To assess very long‐term outcomes of children with severe aplastic anaemia (SAA) and impact histopathology different treatments over time. Methods We conducted a retrospective study 57 consecutive patients SAA during 1973‐2019. According to period, treatment consisted androgens, immunosuppressive (IST) haematopoietic cell transplantation (HCT) in 14, 31 13 patients, respectively. Histopathology immune profiles were studied on bone marrow (BM). Results Response rate (RR)...
Background and aims: JMML is a rare clonal hematopoietic malignancy of childhood. The deregulation the RAS/MAPK signaling pathway caused in more than 90% cases by somatic or germline mutations PTPN11, NRAS, KRAS, NF1, CBL contributes to pathogenesis disease. Clinical molecular risk factors are used stratify patients groups treatment varies from watch-and-wait strategy allogeneic bone marrow transplantation (HSCT), accordingly. aim present case with KRAS-mutated JMML, harboring unfavorable...