A5040264907- Poisoning and overdose treatments
- Forensic Toxicology and Drug Analysis
- Electronic Health Records Systems
- Drug-Induced Hepatotoxicity and Protection
- Emergency and Acute Care Studies
- Cannabis and Cannabinoid Research
- Suicide and Self-Harm Studies
- Information Systems Theories and Implementation
- Technology Adoption and User Behaviour
- Pharmacological Effects and Toxicity Studies
- Opioid Use Disorder Treatment
- Pesticide Exposure and Toxicity
- Plant-based Medicinal Research
- Healthcare Systems and Technology
- Healthcare Decision-Making and Restraints
- Radiation Dose and Imaging
- Cardiac Arrest and Resuscitation
- Venomous Animal Envenomation and Studies
- Digital Mental Health Interventions
- Big Data and Business Intelligence
- Sleep and Wakefulness Research
- Pain Mechanisms and Treatments
- Animal Ecology and Behavior Studies
- Pharmacogenetics and Drug Metabolism
- Disaster Response and Management
The University of Sydney
2014-2024
Sydney Local Health District
2016-2024
Westmead Hospital
2012-2023
Sydney Children’s Hospitals Network
2014-2023
Blacktown & Mount Druitt Hospital
2001-2022
New South Wales Department of Health
2022
Jena University Hospital
2021
South Western Sydney Local Health District
2018
Children's Hospital at Westmead
2006-2017
Western Sydney University
2014
Objectives: To describe the epidemiology and toxicity of caffeinated energy drink exposures in Australia. Design, setting subjects: Retrospective observational study analysing data from calls regarding recorded database an Australian poisons information centre over 7 years to 2010. Main outcome measures: Type exposure; co-ingestants; symptoms reported; reported hospitalisations. Results: Callers 297 drinks, which showed increasing annual trend 12 2004 65 Median age for 217 subjects with...
Context. Brodifacoum is a widely available superwarfarin used as commercial rodenticide. Toxicity from long-acting anticoagulant rodenticides, primarily uncontrolled bleeding, has been reported. Very little published toxicokinetic data are for human brodifacoum poisoning. Management also contentious with uncertainty over the dose, frequency, and duration of antidote treatment vitamin K. The role levels in guiding management not entirely established. Methods. A novel, highly sensitive method...
Previous studies of paracetamol overdose treatment show that a 2-bag, 20-h intravenous (IV) acetylcysteine regimen decreased the incidence non-allergic anaphylactic reactions compared to 3-bag, 21 h IV regimen, but have not examined efficacy 2 bag regimen.This was multi-centre observational study presentations treated with 2-bag (200 mg/kg over 4 h, 100 16 h) 3-bag performed from 2009 2019. Patients were referred emergency department inpatient toxicology units for continued management. For...
Hydroxychloroquine overdose is infrequently reported and the majority of recommendations come from greater experience with chloroquine poisoning. We report two cases massive hydroxychloroquine poisoning (20 g in each case), both which received advanced cardiac life support a treatment regimen consisting sodium bicarbonate, adrenaline potassium. Both these patients survived beyond their initial rapid deterioration cardiovascular collapse to be discharged hospital without sequelae. These had...
Access block (AB) and hospital overcrowding adversely affect ED functionality. throughput measures have been described in the literature with positive impacts on key performance indicators (KPIs)--time to first seen, did-not-wait rates, off-stretcher times for ambulances length of stay figures. In this study, we aimed assess impact a new model care, Senior Streaming Assessment Further Evaluation after Triage (SAFE-T) zone concept statistical outcomes.We implemented care at our tertiary...
Acetylcysteine (NAC), an effective antidote for paracetamol poisoning, is commonly associated with adverse reactions. This has been postulated to be related the rapid initial infusion rate (150 mg/kg over 1 h) of traditional three-bag protocol. We hypothesized that a slower would result in fewer Our institution Western Sydney moved modified two-bag protocol February 2015 - first bag: 200 4 h (50 mg/kg/h) and second (100 16 h).Data was extracted from our database on overdoses treated NAC...
Objectives To learn the attitudes of health professionals, informaticians and information communication technology professionals to using data in electronic records (eHRs) for performance feedback professional development. Design Qualitative research a co-design framework. Health professionals' perceptions accessibility eHRs, barriers enablers these development were explored workshops. Audio recordings workshops transcribed, de-identified, thematically analysed. Setting, participants A total...
Historically, intravenous acetylcysteine has been delivered at a fixed dose and duration of 300 mg/kg over 20 to 21 hours nearly every patient deemed be any risk for hepatotoxicity following acetaminophen overdose. We investigated 12‐hour treatment regimen selected low‐risk patients. This was multicenter, open‐label, cluster‐controlled trial six metropolitan emergency departments. enrolled subjects single or staggered overdose with normal serum alanine transaminase (ALT) creatinine on...
Hospital-treated deliberate self-harm (DSH) is common, costly and has high repetition rates. Since brief contact interventions (BCIs) may reduce the risk of DSH repetition, we aim to evaluate whether a SMS (Short Message Service) text message Intervention plus Treatment As Usual (TAU) compared TAU alone will hospital re-presentation rates in Western Sydney public hospitals Australia. Our study 24-month randomized controlled trial (RCT). Adult patients who present with emergency, psychiatric,...
A rapid, highly sensitive and specific analytical method for the extraction, identification quantification of nine rodenticides from whole blood has been developed validated. Commercially available in Australia include coumatetralyl, warfarin, brodifacoum, bromadiolone, difenacoum, flocoumafen, difethialone, diphacinone chlorophacinone. Waters ACQUITY UPLC TQD system operating multiple reaction monitoring mode was used to conduct analysis. Two different ionization techniques, ES+ ES−, were...
Purpose – This study attempts to understand the factors that influence clinician resistance implementation of health information technology in a mandatory setting.Design/methodology/approach A survey was conducted with 202 clinicians regarding their perceptions electronic medication management systems (eMMS) an Australian hospital. The data collected during initial roll-out eMMS for model validation and quantitative analysis.Findings overall results indicated performance expectancy,...
A 2-year-old boy and a 10-year-old girl presented to the emergency department with decreased level of consciousness. The had persistent vomiting seizure. Urine metabolic screening tests were positive for gamma-hydroxybutyrate (GHB). Samples from toy beads ingested by both children contained 1,4-butanediol, which is metabolised GHB in humans. Regulatory authorities notified, leading an international recall beads.
Abstract Local anaesthesia, in particular retrobulbar block, is commonly used to perform cataract surgery. Known complications of block include cranial nerve palsies, seizures and cardiorespiratory arrest. We report a case brainstem anaesthesia causing apnoea loss consciousness man who received block. The likely mechanism inadvertent dural puncture the optic sheath local anaesthetic injection into cerebrospinal fluid space. As this case, literature reports short‐lived period with usually no...
Poisoning due to chloroform ingestion is rare. The classic features of acute toxicity include central nervous system (CNS) and respiratory depression, delayed hepatotoxicity.A 30-year-old female ingested 20-30 mL 99% solution, which caused rapid loss consciousness, transient hypotension severe depression requiring endotracheal intubation ventilation. She was alert by 12 h extubated 16 post-overdose. At 38-h post-ingestion, her liver function tests started rise she commenced on intravenous...
Poppy seed tea is used for its opioid effects and contains multiple opium alkaloids, including morphine, codeine, papaverine, thebaine. Animal studies indicate thebaine has strychnine-like properties, but there limited literature describing human poisoning. We describe a cluster of acute poisoning in people ingesting made using poppy seeds with high content that entered the Australian food supply chain.This an observational study patients poisoned after drinking tea. Cases were identified by...
In Australia, the treatment guideline for patients with repeated supratherapeutic ingestion (RSTI) of paracetamol recommends an abbreviated acetylcysteine regimen if concentration is low (<10 mg/L) and alanine aminotransferase (ALT) normal or static after 8 hours infusion. There are currently no studies this recommendation.A retrospective review overdose presentations from October 2009 to August 2016 in two hospital toxicology networks was performed. All cases RSTI treated were extracted.Of...