A5080933333- Tuberculosis Research and Epidemiology
- CRISPR and Genetic Engineering
- Mycobacterium research and diagnosis
Weill Cornell Medicine
2021-2022
Cornell University
2021-2022
Mycobacterium tuberculosis (Mtb) infection is notoriously difficult to treat. Treatment efficacy limited by Mtb's intrinsic drug resistance, as well its ability evolve acquired resistance all antituberculars in clinical use. A deeper understanding of the bacterial pathways that influence could facilitate development more effective therapies, identify new mechanisms and reveal overlooked therapeutic opportunities. Here we developed a CRISPR interference chemical-genetics platform titrate...
ABSTRACT Mycobacterium tuberculosis (Mtb) infection is notoriously difficult to treat. Treatment efficacy limited by Mtb’s intrinsic drug resistance, as well its ability evolve acquired resistance all antituberculars in clinical use. A deeper understanding of the bacterial pathways that govern could facilitate development more effective therapies overcome identify new mechanisms and reveal overlooked therapeutic opportunities. To define these pathways, we developed a CRISPR interference...