A5007515930- Neuroscience and Neuropharmacology Research
- Amino Acid Enzymes and Metabolism
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Psychedelics and Drug Studies
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Chemical synthesis and alkaloids
- Neurotransmitter Receptor Influence on Behavior
- ATP Synthase and ATPases Research
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
Multidisciplinary Association for Psychedelic Studies
2024
University of California, Davis
2018-2021
Genentech
2012
Atrophy of neurons in the prefrontal cortex (PFC) plays a key role pathophysiology depression and related disorders. The ability to promote both structural functional plasticity PFC has been hypothesized underlie fast-acting antidepressant properties dissociative anesthetic ketamine. Here, we report that, like ketamine, serotonergic psychedelics are capable robustly increasing neuritogenesis and/or spinogenesis vitro vivo. These changes neuronal structure accompanied by increased synapse...
A series of compounds were designed and synthesized as antagonists cIAP1/2, ML-IAP, XIAP based on the N-terminus, AVPI, mature Smac. Compound 1 (GDC-0152) has best profile these compounds; it binds to BIR3 domain, BIR domain domains cIAP1 cIAP2 with K(i) values 28, 14, 17, 43 nM, respectively. These promote degradation cIAP1, induce activation caspase-3/7, lead decreased viability breast cancer cells without affecting normal mammary epithelial cells. inhibits tumor growth when dosed orally...
d -serine is the primary NMDAR coagonist at mature forebrain synapses and synthesized by enzyme serine racemase (SR). However, our understanding of mechanisms regulating availability synaptic remains limited. Though early studies suggested released from astrocytes, more recent have demonstrated a predominantly neuronal localization SR. More specifically, work intriguingly suggests that SR may be found postsynaptic density, yet functional implications on transmission are not known. Here, we...
NMDA receptors (NMDARs) mediate both long-term potentiation and depression (LTD) understanding how a single receptor can initiate phenomena remains major question in neuroscience. A prominent hypothesis implicates the NMDAR subunit composition, specifically GluN2A GluN2B, dictating rules of synaptic plasticity. However, studies testing this have yielded inconsistent often contradictory results, especially for LTD. These results may be due to challenges interpretation subunit-selective...
There is substantial evidence that both N-methyl-D-aspartate receptor (NMDAR) hypofunction and dysfunction of GABAergic neurotransmission contribute to schizophrenia, though the relationship between these pathophysiological processes remains largely unknown. Although models using cell-type-specific genetic deletion NMDARs have been informative, they display overly pronounced phenotypes extending beyond those schizophrenia. Here, we used serine racemase knockout (SRKO) mice, a model reduced...
Abstract D-serine is the primary NMDA receptor (NMDAR) co-agonist at mature forebrain synapses and synthesized by enzyme serine racemase (SR). However, our understanding of mechanisms regulating availability synaptic remains limited. Though early studies suggested released from astrocytes, more recent have demonstrated a predominantly neuronal localization SR. More specifically, work intriguingly suggests that SR may be found postsynaptic density, yet functional implications on transmission...
Abstract There is substantial evidence that both NMDA receptor (NMDAR) hypofunction and dysfunction of GABAergic neurotransmission contribute to schizophrenia, though the relationship between these pathophysiological processes remains largely unknown. While models using cell-type-specific genetic deletion NMDARs have been informative, they display overly pronounced phenotypes extending beyond those schizophrenia. Here, we used serine racemase knockout (SRKO) mice, a model reduced NMDAR...
Abstract NMDA receptors (NMDARs) mediate major forms of both long-term potentiation (LTP) and depression (LTD) understanding how a single receptor can initiate phenomena remains question in neuroscience. A prominent hypothesis implicates the NMDAR subunit composition, specifically GluN2A GluN2B, dictating rules synaptic plasticity. However, studies testing this hypotheses have yielded inconsistent often contradictory results, especially for LTD. These results may be due to challenges...