Arnab Bose
A5067607818- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Molecular Biology Techniques and Applications
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- Estrogen and related hormone effects
- Hormonal and reproductive studies
Fred Hutch Cancer Center
2022-2023
Advanced prostate cancers comprise distinct phenotypes, but tumor classification remains clinically challenging. Here, we harnessed circulating DNA (ctDNA) to study phenotypes by ascertaining nucleosome positioning patterns associated with transcription regulation. We sequenced plasma ctDNA whole genomes from patient-derived xenografts representing a spectrum of androgen receptor active (ARPC) and neuroendocrine (NEPC) cancers. Nucleosome transcriptional activity were reflected in at regions...
Prostate cancer (PC) is driven by androgen receptor (AR) activity, a master regulator of prostate development and homeostasis. Frontline therapies for metastatic PC deprive the AR activating ligands testosterone (T) dihydrotestosterone (DHT) limiting their biosynthesis or blocking binding. Notably, signaling dichotomous, inducing growth at lower activity levels, while suppressing higher levels. Recent clinical studies have exploited this effect administration supraphysiological...
ABSTRACT Advanced prostate cancers comprise distinct phenotypes, but tumor classification remains clinically challenging. Here, we harnessed circulating DNA (ctDNA) to study phenotypes by ascertaining nucleosome positioning patterns associated with transcription regulation. We sequenced plasma ctDNA whole genomes from patient-derived xenografts representing a spectrum of androgen receptor active (ARPC) and neuroendocrine (NEPC) cancers. Nucleosome transcriptional activity were reflected in...
<div>Abstract<p>Advanced prostate cancers comprise distinct phenotypes, but tumor classification remains clinically challenging. Here, we harnessed circulating DNA (ctDNA) to study phenotypes by ascertaining nucleosome positioning patterns associated with transcription regulation. We sequenced plasma ctDNA whole genomes from patient-derived xenografts representing a spectrum of androgen receptor active (ARPC) and neuroendocrine (NEPC) cancers. Nucleosome transcriptional activity...
<p>Supplementary Figures S1-S18 and Supplementary Table legends.</p>
<p>Supplementary Figures S1-S18 and Supplementary Table legends.</p>
<div>Abstract<p>Advanced prostate cancers comprise distinct phenotypes, but tumor classification remains clinically challenging. Here, we harnessed circulating DNA (ctDNA) to study phenotypes by ascertaining nucleosome positioning patterns associated with transcription regulation. We sequenced plasma ctDNA whole genomes from patient-derived xenografts representing a spectrum of androgen receptor active (ARPC) and neuroendocrine (NEPC) cancers. Nucleosome transcriptional activity...
<p>Supplementary Figures S1-S18 and Supplementary Table legends.</p>