A5081824621- Immune cells in cancer
- MicroRNA in disease regulation
- Hematopoietic Stem Cell Transplantation
- FOXO transcription factor regulation
- Circadian rhythm and melatonin
- Dietary Effects on Health
- Zebrafish Biomedical Research Applications
- Axon Guidance and Neuronal Signaling
University of Florida
2025
UF Health Cancer Center
2023-2024
University of Florida Health
2023-2024
Abstract Aging associated defects within stem cell-supportive niches contribute towards age-related decline in cell activity. However, mechanisms underlying niche defects, and whether restoring function can improve fitness, remain unclear. Here, we sought to determine aged blood be restored by rejuvenating their supportive the bone marrow (BM). We identify Netrin-1 as a critical regulator of BM aging. Niche-specific deletion induces premature aging phenotypes microenvironment, while...
Chronic low-grade inflammation observed in older adults, termed inflammaging, is a common feature underlying multitude of aging-associated maladies including decline hematopoietic activity. However, whether suppression inflammaging can preserve health span remains unclear, part because lack tools to measure within stem cells (HSCs). Here, we identify thrombospondin-1 (Thbs1) as an essential regulator HSCs. We describe transcriptomics-based approach for measuring and demonstrate that deletion...
Abstract In the adult bone marrow (BM), endothelial cells (ECs) are an integral component of hematopoietic stem cell (HSC)-supportive niche, which modulates HSC activity by producing secreted and membrane-bound paracrine signals. Within BM, distinct vascular arteriole, transitional, sinusoidal EC subtypes display unique expression profiles create anatomically-discrete microenvironments. However, relative contributions in supporting hematopoiesis is unclear. Moreover, constitutive off-target...