A5100671778- Cancer Genomics and Diagnostics
- Hormonal and reproductive studies
- Radiomics and Machine Learning in Medical Imaging
- Hedgehog Signaling Pathway Studies
- Drug-Induced Ocular Toxicity
- Cardiac Fibrosis and Remodeling
- Ocular Diseases and Behçet’s Syndrome
- Hormonal Regulation and Hypertension
- Cancer Immunotherapy and Biomarkers
- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Retinal and Optic Conditions
- Nuclear Physics and Applications
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
University of Aveiro
2017-2021
Rede de Química e Tecnologia
2021
Hospital de São João
2020
John Wiley & Sons (United States)
2018
Ecological Society of America
2018
IFC Research (United Kingdom)
2018
Onkovis (Germany)
2016
Abstract A key question in cancer immunotherapy is the general immune status of patient's tumor-microenvironment (TME) prior to therapy. underlying tumor immune-contexture may therefore a) guide therapeutic intervention and b) help identify potential resistance mechanisms immunotherapies. The most commonly used classification patients' based on CD8 infiltrating lymphocytes (TIL) referring either “cold”- or “hot” tumors. Patients early clinical development programs will mostly present with...
Abstract The aim of our study is to understand and characterize tumor biology its metabolism by evaluating some the most relevant hallmarks cancer like hypoxia, apoptosis, proliferation, angiogenesis immune status. We selected from tissue bank FFPE blocks 3 main indications (CRC, GC, RCC) analyzed with 9 different markers: CA9, CC3, Ki67, CD34, aSMA, Podoplanin, CD3, CD8 FOXP3 in consecutive sections. applied 2 triplex, one duplex single IHC assays. After quality check made board certified...
Aim: The goal of this study was to evaluate the therapeutic potential WNT/β-catenin and Hedgehog inhibitors, IWR-1 GDC-0449 respectively, alone in combination, B-cell neoplasms. Introduction: neoplasms include, among others, lymphomas plasma cell disorders, such as multiple myeloma (MM), a malignant neoplasm originated by proliferation monoclonal cells; diffuse large lymphoma (DLBCL), most common form non-Hodgkin lymphoma. Inappropriate activation conserved embryonic signaling pathways, has...
Purpose: We aim to report an atypical case of optic neuropathy associated with amiodarone a rapid development that presented unilateral disc edema and, consecutively, developed in the contralateral eye. Case report: An 80-year-old patient, taking for 2 months, progressive bilateral decrease visual acuity, more marked left eye (OS). The observation revealed acuity (VA) right (OD) 4/10, counting fingers OS, relative afferent pupillary defect, and papillary eye. In subsequent consultation, OD...