A5023346415- Cardiac Fibrosis and Remodeling
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Signaling Pathways in Disease
- Atherosclerosis and Cardiovascular Diseases
- CAR-T cell therapy research
- Viral Infections and Immunology Research
- Receptor Mechanisms and Signaling
- Cardiac electrophysiology and arrhythmias
Universitätsklinikum Würzburg
2018-2023
Abstract Aims Recent studies have revealed that B cells and antibodies can influence inflammation remodelling following a myocardial infarction (MI) culminating in heart failure—but the mechanisms underlying these observations remain elusive. We therefore conducted mice deep phenotyping of post-MI B-cell responses infarcted hearts mediastinal lymph nodes, which drain myocardium. Thereby, we sought to dissect controlling mobilization activity situ. Methods results Histological, flow...
The cardiovascular and immune systems undergo profound intertwined alterations with aging. Recent studies have reported that an accumulation of memory terminally differentiated T cells in elderly subjects can fuel myocardial aging boost the progression heart diseases. Nevertheless, it remains unclear whether immunological senescence profile is sufficient to cause age-related cardiac deterioration or merely acts as amplifier previous tissue-intrinsic damage. Herein, we sought decompose...
Heart-specific antibodies have been widely associated with myocardial infarction (MI). However, it remains unclear whether autoantibodies mediate disease progression or are a byproduct of cardiac injury. To disambiguate the role immunoglobulins in MI, we characterized development ischemic heart failure agammaglobulinemic mice (AID −/− μS ). Although these animals can produce functional B cells, they cannot synthesize secretory IgM (μS ) perform Ig class switching ), leading to complete...
Abstract Myocardial infarction (MI) is associated with an inflammatory process mainly attributed to innate immune components. Very recently, the role of T-cells in both inflammation and healing has been suggested through various human mouse studies. Previous studies showed that CD4+ CD8+ T cells affect post-MI repair but did not investigate how leverage cell biology predict outcomes patients. For instance, antigenic trigger still unknown human. Indeed, others we identified T-cell specific...